中藥大生命科學(xué)與技術(shù)學(xué)院導(dǎo)師：顧月清 正文

　　顧月清博士,中國藥科大學(xué)生命科學(xué)與技術(shù)學(xué)院生物醫(yī)學(xué)工程學(xué)教授，博士生導(dǎo)師。國際光學(xué)工程協(xié)會（SPIE）及美國光學(xué)學(xué)會（OSA）會員，中國光學(xué)學(xué)會生物醫(yī)學(xué)光子學(xué)專業(yè)委員會理事，中國電子學(xué)會醫(yī)學(xué)影像專業(yè)委員會理事，中國生物醫(yī)學(xué)工程學(xué)會分子影像分會理事，江蘇省計量測試學(xué)會理事，江蘇省生物醫(yī)學(xué)工程生物光子學(xué)會理事，江蘇省“青藍(lán)工程”中青年學(xué)術(shù)帶頭人，多種國際雜志的特約審稿人（J. Controlled Release, Optics Express, Bioconjugate Chemistry，Cancer Investigation, J. Fluorescence, Journal of Pharmaceutical Science, Pharmaceutical Research），國家自然科學(xué)基金、教育部、科技部、部分省市科技廳等基金通訊及會議評審專家。
　　顧月清教授1997年于南京航空航天大學(xué)測試計量技術(shù)及儀器專業(yè)獲得博士學(xué)位，1999年至2004年先后在美國賓州大學(xué)（University of Pennsylvania）醫(yī)學(xué)院及德州大學(xué)(University of Texas)西南醫(yī)學(xué)中心從事博士后研究工作，并于2003年被聘為德州大學(xué)阿靈頓分校生物醫(yī)學(xué)工程系助理教授。期間作為課題負(fù)責(zé)人獲得美國國防部博士后基金及新研究者基金的資助，集中于近紅外技術(shù)對乳腺癌及前列腺癌等的早期診斷及監(jiān)測治療研究。
　　顧月清教授于2005年回國后建立生物醫(yī)學(xué)工程實驗室，近年來一直致力于分子成像技術(shù)在藥物研發(fā)各領(lǐng)域的應(yīng)用，研究方向集中在如下四個方面：1）各種腫瘤特異性標(biāo)志物的靶向分子探針的研究，以實現(xiàn)腫瘤的早期分子診斷；2）各種高分子納米藥物載體的研究，以實現(xiàn)腫瘤的主動/被動靶向治療；3）從基因水平設(shè)計特異性DNA序列探針及分子信標(biāo)，以研究腫瘤的生長、發(fā)展、轉(zhuǎn)移等相關(guān)信號通路的關(guān)鍵蛋白，以研究腫瘤生長機(jī)制；4）開發(fā)各種熒光探針及光學(xué)檢測系統(tǒng)，實現(xiàn)大分子藥物體內(nèi)動力學(xué)過程的無損在位實時監(jiān)測及動力學(xué)特性研究；
　　自2006年，顧月清教授先后主持5項國家自然科學(xué)基金項目、指導(dǎo)3項國家自然基金青年基金項目、主持3項國際合作研究基金項目，參加科技部重大專項及多項省部級基金，申請及獲國家發(fā)明專利8項。自2007年至今，共發(fā)表學(xué)術(shù)論文55篇，其中在國際權(quán)威雜志發(fā)表了SCI收錄論文近30篇，總累計影響因子超過100、19篇EI收錄研究論文。

　　在研項目：
　　國家自然科學(xué)基金重大國際（地區(qū)）合作研究項目（81220108012）
　　題目：面向乳腺腫瘤高轉(zhuǎn)移機(jī)制的量子點(diǎn)小動物活體標(biāo)記新方法的基礎(chǔ)研究                       
　　時 間： 2013.1~2017.12  經(jīng)費(fèi)：280 萬
　　分 工：項目主持人 (顧月清)
　　國家自然科學(xué)基金面上項目(81171395)
　　題目： 基于SPR 的納米熒光分子探針活細(xì)胞內(nèi)腫瘤藥敏基因的檢測及其穿膜特性的研究                       
　　時 間： 2012.1~2015.12  經(jīng)費(fèi)：61萬
　　分 工：項目主持人 (顧月清)

　　國家自然科學(xué)基金面上項目(30970776) ：
　　題 目：基于近紅外量子點(diǎn)的分子成像對惡性腫瘤的代謝特性及特異性標(biāo)志物的雙重診斷
　　時 間： 2010.1~2012.12  經(jīng)費(fèi)：33萬
　　分 工：項目主持人 (顧月清)
　　國家自然科學(xué)基金外國青年學(xué)者研究基金(31050110123) ：
　　題 目：Measurement of cancer-related protease activity using activatable fluorescent molecular probes in vivo
　　時 間： 2010.7~2012.6， 經(jīng)費(fèi)： 40萬
　　分 工：項目主持人Walter John Akers from USA,  中方合作者：顧月清

　　 

　　近幾年發(fā)表的論文：
　　Dawei Deng, Yuqi Chen, Jie Cao, Junmei Tian, Zhiyu Qian, Samuel Achilefu, Yueqing Gu*, High-Quality CuInS2/ZnS Quantum Dots for in vitro and in vivo Bioimaging, Chemistry of Materials, 2012, 24(15), 3029–3037. (IF=7.268)
　　Haiyan Chen, Shulan Li, Xueyan Ren, Shengnan Li, Yueqing Gu*. Folate-modified gold nanoclusters as near-infrared fluorescent probes for tumor imaging and therapy. Nanoscale, 2012, DOI:10.1039/C2NR31616A. (IF=5.914)
　　Haiyan chen, bowen Li, Xueyan Ren, Shengnan Li Yuxiang Ma, Sisi Cui, Yueqing Gu*. Multifunctional near-infrared-emitting nano-conjugates based on gold clusters for tumor imaging and therapy. Biomaterials, 2012, http://dx.doi.org/10.1016/j.biomaterials.2012.08.034. (IF=7.404)
　　Jian Zhang, Dawei Deng, Hongyan Zhu, Youngro Byun, Victor C. Yang, Yueqing Gu*, “ Folate-conjugated thermo-responsive micelles for tumor targeting, Journal of Biomedical Materials Research: Part A, 2012 in press  

　　Mahounga DM, Shan Lingling, Jie Cao, Du Changli, Wan Sunan, Gu Yueqing*, “”, Mol Imaging Biol. 2012 May 3. [Epub ahead of print].

　　Jianpeng Xue, Haiyan Chen, Bing Xue, Zhiyu Qian, Walter J. Akers, Samuel Achilefu, Yueqing Gu*, “Visual Detection of STAT5B Gene Expression in Living Cell using the hairpin DNA modified gold nanoparticles beacon”, Biosensors and Bioelectronics (IF=5.1), 2012，in press.  

　　Jing Chen , Haiyan Chen , Sisi Cui , Bing Xue , Junmei Tian , Samuel Achilefu, Yueqing Gu *, Glucosamine Derivative Modified Nanostructured Lipid Carriers for Targeted Tumor Delivery, J.Material Chemistry. 2012, 22, 5770-5783 (IF=5.1) SCI-CD

　　SCI-CD

　　Jie Cao, Shunan Wan, Junmei Tian, Siwen Li, Dongyin Zhang, Dawei Deng, Zhiyu Qian, Yueqing Gu*. Fast Clearing RGD-Based Near Infrared Fluorescent Probes for in vivo Tumor Diagnosis. Contrast Media and Molecular Imaging, 2012, 7(4):390-402（IF=4.1）SCIE

　　Jing Guo, Changli Du, Lingling Shan, Hongyan Zhu, Bing Xue, Zhiyu Qian, Samuel Achilefu, Yueqing Gu*. Comparison of near infrared fluorescent deoxyglucose probes with different dyes for tumor diagnosis in vivo. Contrast Media and Molecular Imaging, 2012, 7(3):289-301 (IF=4.1)SCIE

　　Hui Li, Zhenzhen Tu (co-author), Lianxiao An, Zhiyu Qian, Samuel Achilefu, Yueqing Gu*. Inhibitory effects of ERβ on proliferation, invasion and tumor formation of MCF-7 breast cancer cells-prognostication for the use of ERβ-selective therapy. Pharmaceutical biology,2012, 50(7):839-49 (IF=0.638)SCIE

　　Bing Xue, Dawei Deng, Jie Cao, Fei Liu, Xin Li, Walter Akers ,Samuel Achilefu, and Yueqing Gu. Synthesis of NAC Capped Near Infrared-Emitting CdTeS Alloyed Quantum Dots and Application for in vivo Early Tumor Imaging. Dalton Transactions, 2012, 41(16):4935-47 (IF=3.647)SCI-CD

　　Jie Cao, Hongyan Zhu (co-author), Dawei Deng, Bing Xue, Liping Tang, Didel Mahounga, Zhiyu Qian, Yueqing Gu*. In vivo NIR imaging with PbS quantum dots entrapped in biodegradable micelles. Journal of Biomedical Materials Research: Part A, 2012, 100(4):958-68 (IF=3.1)SCI-CD

　　Dawei Deng, Junfei Xia, Jie Cao, Lingzhi Qu, Junmei Tian, Zhiyu Qian, Yueqing Gu, Zhongze Gu. Forming highly fluorescent near-infrared emitting PbS quantum dots in water using glutathione as surface-modifying molecule. J Colloid Interface Sci. 2012, 367(1):234-40 (IF=3.1) SCI

　　Lingling Shan, Jianpeng Xue, Zhiyu Qian, Samuel Achilefu, Yueqing Gu*. Improved Targeting of Ligand-Modified Adenovirus as a New Near Infrared Fluorescence Tumor Imaging Probe. Bioconjugate Chemistry, 2011, 22: 567-581.(IF=5.1) SCI

　　Lingling Shan, Sisi Cui, Changli Du, Shunan Wan, Zhiyu Qian, Samuel Achilefu, Yueqing Gu*. A paclitaxel-conjugated adenovirus vector for targeted drug delivery for tumor therapy. Biomaterials, 2011, 33(1): 146-162. (IF=7.8) SCI

　　Hongyan Zhu, Fei Liu, Jing Guo, Jianpeng Xue, Zhiyu Qian, Yueqing Gu*. Folate-modified chitosan micelles with enhanced tumor targeting evaluated by near infrared imaging system. Carbohydrate Polymers, 2011, 86(3): 1118-1129 (IF=3.7) SCI

　　Haiyan Chen, Sisi Cui, Zhenzhen Tu, Jinzi Ji, Jun Zhang, Yueqing Gu*. Characterization of CdHgTe/Cds QDs for Near Infrared Fluorescence Imaging of Spinal Column in a Mouse Model. Photochemistry and Photobiology, 2011, 87: 72-81. (IF=2.8) SCI

　　Haiyan Chen, Li Li, Sisi Cui, Dider Mahounga, Jun Zhang, Yueqing Gu*. Folate Conjugated CdHgTe Quantum Dots with High targeting Affinity and Sensitivity for In vivo Early Tumor Diagnosis. J Fluoresc, 2011, 21: 793~801.(IF=2.6) SCI

　　Fang-qiu Li, Shi-xin Zhang, Lian-xiao An, Yueqing Gu*, “ In vivo molecular targeting effects of anti-Sp17-ICG-Der-02 on hepatocellular Carcinoma evaluated by an optical imaging system”, Journal of Experimental &Clinical Cancer Research, 2011, 30:25  （IF1.27）SCIE

　　Dawei Deng, Jie Cao, Junfei Xia, Zhiyu Qian, Yueqing Gu*, Zhongze Gu,* and Walter John Akers, “Two-phase Approach to High Quality, Oil-soluble, Near-infrared-emitting PbS Quantum dots by Using Various Water-soluble Anion Precursors”, Eur. J. Inorg. Chem.2011 ( IF=2.941)SCI

　　Jie Cao, Shunan Wan, Junmei Tian, Xuemei Chi, Changli Du, Dawei Deng, Wei R. Chen, Yueqing Gu*. Synthesis of dimeric cyclic RGD based near-infrared probe for in vivo tumor diagnosis. Proc. of SPIE, 2012, accepted. EI

　　Sisi Cui, Hongyan Zhu, Haiyan Chen, Junmei Tian, Wei R. Chen, Yueqing Gu*. Surface modification of upconversion nanoparticles with amphiphilic chitosan for cancer cell imaging. Proc. of SPIE, 2012, accepted.EI

　　Sisi Cui, Haiyan Chen, Yueqing Gu*, “Comparison of Two Strategies for the Synthesis of Upconverting Nanoparticles as Biological labels”, Journal of Physics: Conference Series 277 （2012） 012006 (EI)
　　Xuemei Chi, Jie Cao, Shunan Wan, Changli Du, Wei R. Chen, Yueqing Gu*. Synthesis and characterization of NIR-triggered polyelectrolyte multilayer capsules. Proc. of SPIE, 2012, accepted. EI

　　Junmei Tian ,Zhenzhen Tu ,Wei R.Chen,Yueqing Gu*. ERβ regulates miR-21 expression and inhibits invasion and metastasis in cancer cells. Proc. of SPIE, 2012, accepted. EI

　　Jianpeng Xue, Lingling Shan, Zhenzhen Tu, Hongyan Zhu, Haiyan Chen, Dawei Deng, Zhiyu Qian, Yueqing Gu*. Synthesis of Gold nanoparticle based beacon for measurement of STAT5b protein expression. Proc. of SPIE, 2011, 7910: 791001-1.EI

　　Haiyan Chen, Sisi Cui (co-author), Hongyan Zhu, Zhenzhen Tu, Lingling Shan, Jianpeng Xue, Dawei Deng, Jun Zhang, Yueqing Gu*. In vivo monitoring of Organ-Selective distribution of CdHgTe/SiO2. Proc. of SPIE, 2011, 7910: 79100S-1.EI

　　Jian Zhang, Dawei Deng, Yueqing Gu*, “The Targeting Behavior of Folate-Nanohydrogel Evaluated by Near Infrared Imaging System in Tumor-Bearing Mouse Model” Pharmaceutical Research, 2010, 27(1): 46-55. (IF=3.277) SCI

　　Jie Cao, Bing Xue, Hui Li, Dawei Deng, Yueqing Gu*. Facile synthesis of high-quality water-soluble N-acetyl-L-cysteine-capped Zn1-xCdxSe/ZnS core/shell quantum dots emitting in the violet–green spectral range. Journal of Colloid and Interface Science, 2010, 348, 369-376. (IF=3.019)SCI

　　Haiyan Chen, Sisi Cui, Jun Zhang, Yueqing Gu*, “Folated conjugated CdHgTe quantum Dots with high targeting affinity and sensitivity for in vivo early tumor diagnosis. Journal of Fluorescence, 2010. In press.(IF=2.1) SCI

　　Fei Liu, Dawei Deng, Xinyang Chen, Zhiyu Qian, Samuel Achilefu, Yueqing Gu*, “Folate-polyethylene glycol conjugated near infrared fluorescence probe with high targeting affinity and sensitivity for in vivo early tumor diagnosis”, Molecular Imaging & Biology, 2010, In press (IF=2.467)SCIE

　　Dawei Deng, Fei Liu, Jie Cao, Xinyang Chen, and Yueqing Gu *, “Synthesis and Tumor Targeting Research of Two Near-Infrared Fluorescence Probes”, Chinese Journal of Lasers, 2010, In Press. (EI)

　　Jie Cao, Dawei Deng*, Yueqing Gu*, “Uniform Mesoporous Dye-Doped Silica Nanoparticles as a Multifunctional Drug Carrier for in vivo early tumor diagnosis”, Proc. SPIE, 2010, In Press.(EI)

　　Ting Li, Nanxi Wang, Lijia Chen, Dawei Deng, Yueqing Gu*, “Use of water-soluble PbS quantum dots as fluorescent probe in sensing copper(II)”, Proc. SPIE, 2010, In Press.(EI)
　　Hongyan Zhu, Dawei Deng, Haiyan Chen, Zhiyu Qian, Yueqing Gu, “The targeted behavior of folate-decorated N-succinyl-N’-octyl chitosan evaluated by NIR system in mouse model”, Proc. SPIE, 2010, In Press.(EI)

　　Jie Cao, Bing Xue, Hui Li, Dawei Deng*, Yueqing Gu*, “Facile synthesis of high-quality water-soluble N-acetyl-L-cysteine-capped Zn1-xCdxSe/ZnS core/shell quantum dots emitting in the violet–green spectral range”, J. Colloid Interface Sci., 2010, 348, 369–376. (IF=3.1)SCI

　　Jie Cao, Shan Li, Dawei Deng and Yueqing Gu *, “Preparation and characterization of water-soluble near-infrared emission PbS quantum dots”, Transactions of Nanjing University of Aeronautics & Astronautics, 2010, 27(1), 81–87.

　　Yueqing Gu, Fei Liu, Chunsheng Fang, Zhiyu Qian, Samuel Achilefu, “ In vivo investigation of pharmacokinetics of model drug: comparison of near infrared technique with high performance liquid chromatography” Invited paper, Proc. SPIE, 2010, vol.7576. EI

　　Dawei Deng, Xinyang Chen, Jian Zhang, Fei Liu, Jie cao, and Yueqing Gu*, “Aqueous synthesis of PbS quantum dots for noninvasive near-infrared fluorescence imaging in a mouse model”, Proc. SPIE, 2010, Vol. 7576.EI

　　Jie Cao, Hongyan Zhua, Dawei Deng, Bing Xue, Liping Tang, Didel Mahounga, Zhiyu Qian, Yueqing Gu*, Facile Synthesis of Near-Infrared PbS Quantum Dots for In Vivo Tracing of Micelles, submitted to physical chemistry chemical physics (IF=4.116)

　　Jian zhang, Yueqing Gu*, “In vivo anti-tumor efficacy of docetaxel-loaded thermally responsive nanohydrogel”, Nanotechnology, Vol. 20, pp 325102-325109, 2009.（IF=3.137）SCI

　　Huimin Qian, Yueqing Gu*, Min Wang and Samuel Achilefu, “Optimization of the Near-Infrared Fluorescence Labeling for In Vivo Monitoring of a Protein Drug Distribution in Animal Model”, J. Fluoresc. (2009) 19:277–284.（IF=2.017）SCI

　　Yueqing Gu*, , , and , “Dynamic properties of different kinds of nanoparticles in mouse model after intravenous administration” , 71900F. (EI)

　　Xinyang Chen, Dawei Deng, zhiyu Qian, Yueqing Gu*, “In vivo tumor imaging in mice with near-infrared - low density lipoprotein conjugates”, Proc. SPIE, 2009, Vol. 7519, 75190P. (EI)
　　Dawei Deng, Wenhao Zhang, Xinyang Chen, Fei Liu, Jian Zhang, Yueqing Gu*, and Jianming Hong, “Facile Synthesis of High-Quality, Water-Soluble, Near-Infrared-Emitting PbS Quantum Dots”, Eur. J. Inorg. Chem. 2009, 3440–3446.（IF=2.941）SCI

　　Dawei Deng, Peng Li, and Yueqing Gu*, “Synthesis and structural analysis of angled Te nanocrystals” Cryst. Res. Technol. 2009, 44, No. 6, 629–635.（IF=2.293）SCI

　　Dawei Deng, and Yueqing Gu*, “Spontaneous transition and concomitant self-assembly of CdTe nanoparticles into CdS nanosheets induced by L-cysteine”, Proc. of SPIE, 2009, Vol. 7190.EI

　　Jian Zhang, Lin Xu, Yueqing Gu*, “The targeted behavior of thermally responsive nanohydrogel evaluated by NIR system in mouse model” J. controlled release.131:34-40, 2008..(IF=5.949)
　　SCI

　　Haiyan Chen, Yueqing Gu*, Yuzhu Hu, Real time in vivo non-invasive optical imaging of temperature sensitive co-polymeric nanohydrogel, Nanotechnology, 2008, 19, 18570.（IF=3.137）SCI

　　Huimin Qian Yueqing Gu*, Minwang, Samuel Achilefu, “Optimization of the near-infrared fluorescence labeling for in vivo monitoring of a protein drug distribution in animal model” J Fluorescence, 2008 (Epub ahead of print) （IF=2.017） SCI

　　Yueqing Gu, Zhiyu Qian, Yunli Song,  In Vivo Near Infrared Techniques for Protein Drug Development, Encyclopaedia  of  Heathcare Information System,  Bookchapter, 2008

　　Haiyan Chen, Yuanqing Wang, Jing Xu, Jian Zhang, Yuzhu Hu, Yueqing Gu* , Non-invasive Near Infrared Fluorescence Imaging of CdHgTe Quantum Dots in Mouse Model.J Fluoresc. 18(5):801-11,2008 (IF=2.017) SCI

　　Haiyan Chen, Yueqing Gu*, Yuzhu Hu, “Comparison of two polymeric carrier formulations for controlled release of hydrophilic and hydrophobic drugs”, Journal of Materials Science: Materials in Medicine, 2008 Feb;19(2):651-8.(IF=1.955) SCI

　　Haiyan Chen, Yueqing Gu*, Yuzhu Hu, Zhiyu Qian, “Characterization of pH and temperature sensitive hydrogen nanoparticle for controlled drug release, PDA Journal of Pharmaceutical Science and Technology, 2007, Jul-Aug;61(4):303-13

　　Hao Gao, Yueqing Gu*, Qingneng Ping*, “The implantable 5-fluororacil-loaded poly (L-lactic acid) fibers prepared by wet-spinning from suspension”, Journal of Controlled Release, 2007 Apr ;118(3):325-32. (IF=5.949)  SCI

　　Chunsheng Fang, Yueqing Gu.Near-infrared fluorescence labeling and in vivo monitoring of the dynamics of insulin in mouse model, The 6th international conference on photonics and imaging in biology and medicine.2007

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