楊儉 ，女，1961年12月出生，博士。南京醫(yī)科大學藥理系教授、碩士生導師、系副主任。江蘇省“六大人才高峰” B類培養(yǎng)對象。2004.7~2008.6美國羅得島大學藥學院作訪問學者，從事藥物代謝酶的轉錄（核受體）調節(jié)，藥物、草藥、激素之間的相互作用的研 究。期間申請并獲得主持美國NIH postdoctoral 基金1項。

研究興趣和方向：
神經藥理學和臨床藥理學。

目前主持課題：
美國NIH International postdoctoral fellowship grant, “Transcription Activation-Based Herb-Drug Interactions (PA03-050 - 1 F05 AT003019-01 ) (2005－2010)”
國家自然科學基金“在對IL6的反應中DEC1負性調節(jié)肝臟藥物代謝酶CYP3A4表達（30772616）（2008－2010）”

近期發(fā)表論文：
Jian Yang, Deshi Shi, Dongfang Yang, Xiulong Song, and Bingfang Yan. Interleukin-6 Alters the Cellular Responsiveness to Clopidogrel, Irinotecan, and Oseltamivir by Suppressing the Expression of Carboxylesterases HCE1 and HCE2. Mol Pharmacol 2007, 72(3):684-694
Yang J, Yan B. Photochemotherapeutic agent 8-methoxypsoralen induces Cytochrome P450 3A4 and Carboxylesterase HCE2: Evidence on an Involvement of the Pregnane X Receptor. Toxicol Sci.2007；95（1）：13-22
Jian Yang, Jack Champitelli, Gang Hu, Yanhe Lin, Jin Luo, Chun Xue. Increase in DPP-IV in the intestine, liver and kidney of the rat treated with high fat diet and streptozotocin. Life Sci. 2007, 81:272-279.
Yang J, Hu LF, Liu X, Zhou F, Ding JH, Hu G. Effects of iptakalim on the extracellular glutamate and dopamine levels in the striatum of unilateral 6-hydroxydopamine-lesioned rats: a microdialysis study. Life Sci.2006, 78(17):1940-4.
Li Y, Xie M, Yang J, Yang D, Deng R, Wan Y, Yan B. The expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter. Oncogene. 2006 Jun 1;25(23):3296-306.
Shi D, Yang J, Yang D, Lucluyse EL, Black C, You L,Akhlaghi F, Yan B . Anti-Influenza viral prodrug oseltamivir is activated by carboxylesterase and the activation is inhibited by ?anti-platelet agent clopidogrel. J Pharmacol Exp Ther. 2006;319(3):1477-84.

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