西北農(nóng)林科技大學(xué)生命科學(xué)學(xué)院導(dǎo)師：沈錫輝 正文

　　沈錫輝，男，1972年11月出生，陜西省商州市丹鳳縣人，1994年本科畢業(yè)于西北農(nóng)業(yè)大學(xué)農(nóng)學(xué)系，1997年碩士研究生畢業(yè)于西北農(nóng)業(yè)大學(xué)基礎(chǔ)科學(xué)系，2005年在中科院微生物所獲微生物學(xué)博士學(xué)位，2005-2008年為美國普度大學(xué)生物科學(xué)系博士后，2008-2010年被聘為中科院武漢病毒所病毒學(xué)國家重點實驗室副研究員，現(xiàn)為西北農(nóng)林科技大學(xué)生命科學(xué)學(xué)院教授，博士生導(dǎo)師。
　　主要研究方向為微生物分子生理學(xué)和生物化學(xué)，以谷氨菌棒桿菌、嗜肺軍團菌、假結(jié)核耶爾森氏菌等重要的模式微生物為模型，利用生物化學(xué)、分子生物學(xué)、遺傳學(xué)和功能基因組學(xué)技術(shù)進行微生物重要代謝途徑、致病因子的分子生理學(xué)研究，并在此基礎(chǔ)上發(fā)現(xiàn)重要的藥物作用靶標(biāo)，以及設(shè)計新的代謝工程策略，通過對微生物進行系統(tǒng)生物技術(shù)改造，從而利用微生物技術(shù)進行污染物的降解和生物質(zhì)源大宗化學(xué)品的合成，以及為病原微生物的防治提供理論指導(dǎo)和技術(shù)支持。在PLos Pathogens, Cellular Microbiology, Applied and Environmental Microbiology等國際著名期刊發(fā)表研究論文10余篇，是國際期刊Archives of Microbiology的審稿人。

　　部分發(fā)表文章：
　　Li Xu*, Xihui Shen*, Andrew Bryan, Simran Banga, Michele S. Swanson, Zhao-Qing Luo. Inhibition of Host Vacuolar H -ATPase Activity by a Legionella pneumophila effector. PLos Pathogens. 2010，19;6(3):e1000822.（* Co-first Author）
　　Xihui Shen, Simran Banga, Yancheng Liu, Li Xu, Ping Gao, Ilya Shamovsky, Evgeny Nudler, Zhao-Qing Luo. Targeting eEF1A by a Legionella pneumophila effector leads to inhibition of protein synthesis and induction of host stress response. Cellular Microbiology. 2009, 11(6):911-26.
　　Banga S, Gao P, Shen XH, Fiscus V, Zong WX, Chen L, Luo ZQ. Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 family. PNAS 2007，104(12):5121-6.
　　Yan Huang, Kexin Zhao, Xihui Shen, Chengying Jiang, and Shuang-Jiang Liu. Genetic and biochemical characterization of a 4-hydroxybenzoate hydroxylase from Corynebacterium glutamicum. Applied Microbiology and Biotechnology 2008, 78(1):75-83.
　　Chaudhry MT, Huang Y, Shen XH, Poetsch A, Jiang CY, Liu SJ. Genome-wide investigation of aromatic acid transporters in Corynebacterium glutamicum. Microbiology. 2007，153(3):857-65.
　　Huang Y, Zhao KX, Shen XH, et al. Genetic characterization of the resorcinol catabolic pathway in Corynebacterium glutamicum. Applied and Environmental Microbiology 2006，72(11):7238-45.
　　Jie Feng, Yongsheng Che, Johanna Milse, Ya-Jie Yin, Lei Liu, Christian, Rückert, Xi-Hui Shen, Su-Wei Qi, Jörn Kalinowski, and Shuang-Jiang Liu. The gene ncgl2918 encodes a novel maleylpyruvate isomerase that needs mycothiol as cofactor and links mycothiol biosynthesis and gentisate assimilation in Corynebacterium glutamicum. Journal of Biological Chemistry. 2006， 281(16):10778-85.
　　Xihui Shen, Chengying Jiang, Yan Huang, Zhipei Liu, and Shuang-Jiang Liu. Functional identification of novel genes involved in the glutathione-independent gentisate pathway in Corynebacterium glutamicum. Applied and Environmental Microbiology 2005，71(7):3442-52.
　　Xi-Hui Shen, Yan Huang，Shuang-Jiang Liu Genomic analysis and identification of catabolic pathways for aromatic compounds in Corynebacterium glutamicum. Microbes and Environments. 2005. 20(3):160-167.
　　Xihui Shen, Shuang-Jiang Liu. Molecular basis of the protocatechuate branch of the β-ketoadipate pathway for aromatic degradation in Corynebacterium glutamicum. Science in China 2005, 48: 241-249.
　　Xihui Shen, Zhipei Liu, and Shuang-Jiang Liu. Functional identification of the gene locus (ncg12319) and characterization of catechol 1,2-dioxygenase in Corynebacterium glutamicum. Biotechnology Letters 2004, 26:575-580.

　　通訊地址：陜西楊凌邰城路3號西北農(nóng)林科技大學(xué)生命科學(xué)學(xué)院
　　郵編：712100
　　聯(lián)系電話：18966833023
　　Email: xihuishen@yahoo.com.cn
　　 
　　Xihui Shen, Ph. D., Professor
　　Tel: 86-10-18966833023
　　E-mail: xihuishen@yahoo.com.cn
　　Education and Training
　　1990-1994: B.Sc., Genetics and Breeding, Department of Agronomy, Northwestern Agricultural University
　　1994-1997: M.Sc., Biochemistry, Department of Basic Sciences, Northwestern Agricultural University
　　2001-2005: Ph.D, Biochemistry and Molecular Biology, Institute of Microbiology, Chinese Academy of Sciences
　　2005-2008: Post-Doctoral Research Associate, Cellular Microbiology, Department of Biological Sciences, Purdue University
　　Professional Appointments
　　1997-2001: Assistant Professor, Hubei Bt Research and Development Center, Wuhan
　　2008-2010: Associate Professor, Wuhan Institute of Virology, CAS
　　2010- Professor and Ph.D Advisor, College of Life Sciences, Northwest A&F University
　　Research Interests
　　Microbial physiology and biochemistry; Biodegradation of aromatic compounds; Bacteria-host interactions; Metabolic engineering.
　　Selected Publications
　

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