南華大學公共衛(wèi)生學院導師：楊細飛 正文

[導師姓名]
楊細飛

[所屬院校]
南華大學

[基本信息]
導師姓名：楊細飛
性別：男
人氣指數(shù)：6036
所屬院校：南華大學
所屬院系：公共衛(wèi)生學院
職稱：研究員
導師類型：
招生專業(yè)：公共衛(wèi)生碩士

[通訊方式]
辦公電話：0755-25601914
電子郵件：xifeiyang@gmail.com
通訊地址：廣東省深圳市南山區(qū)龍苑路8號

[個人簡述]
獲廣東省科學技術獎二等獎、中華醫(yī)學獎三等獎、深圳市自然科學獎一等獎及深圳市科技進步獎二等獎各1項。國際學術期刊J Alzheimers Dis雜志副編輯（Associate Editor）及Front Neurosci雜志編委；10多個國際主流SCI期刊審稿專家。

[科研工作]
2005/8-2007/7 香港大學，醫(yī)學院，訪問學者2007/8-2009/7 香港大學，醫(yī)學院，訪問學者/博士后2009/8-至今 深圳市疾病預防控制中心/深圳市預防醫(yī)學研究所，廣東省醫(yī)學重點實驗室 副研究員、深圳大學特約教授、四川大學華西醫(yī)學中心（原華西醫(yī)科大學）客座副教授 碩士研究生導師1. Ming Ying, Xiaojing Sui,Yanling Zhang, Qian Sun, Zhongsen Qu, Xiaobin Luo, Raymond Chuen-Chung Chang, Jiazuan Ni, Jianjun Liu and Xifei Yang*(通訊作者). Identification of Novel Key Molecules Involved in Spatial Memory Impairment in Triple Transgenic Mice of Alzheimer’s Disease. Mol Neurobiol. 2016, In press. (2015最新影響因子: 5.137)2. Qian Sun, Ming Ying, Quan Ma, Zhijun Huang, Liangyu Zou, Jianjun Liu, Zhixiong Zhuang, Xifei Yang*(通訊作者). Proteomic Analysis of Hippocampus in Mice Following Long-term Low Levels of Copper. Toxicol Res. 2016, Accepted. (2015最新影響因子: 3.983)3. Xing R, Zhang Y, Xu H*, Luo X, Chang RC, Liu J, Yang X* (通訊作者). Spatial memory impairment by TRPC1 depletion is ameliorated by environmental enrichment. Oncotarget. 2016 Mar 28. doi: 10.18632/oncotarget.8428. [Epub ahead of print]. [PMID: 27034165]. (2015最新影響因子: 6.359)4. Wu Y, Luo X, Liu X, Liu D, Wang X, Guo Z, Zhu L, Tian Q, Yang X* (通訊作者), Wang JZ*. Intraperitoneal Administration of a Novel TAT-BDNF Peptide Ameliorates Cognitive Impairments via Modulating Multiple Pathways in Two Alzheimer's Rodent Models. Sci Rep. 2015 Oct 14 5:15032. [PMID: 26463268]. (2015最新影響因子: 5.578)5. Yang X* (通訊作者), Zhang Y, Xu H, Luo X, Yu J, Liu J, Chang RC. Neuroprotection of Coenzyme Q10 in Neurodegenerative Diseases. Curr Top Med Chem. 2016 16(8):858-866. (特邀綜述) . (2015最新影響因子: 3.402)6. Zhang Y, Xing R, Luo X, Xu H, Chang RC, Zou L, Liu J, Yang X* (通訊作者). Anxiety-like Behavior and Dys-regulation of miR-34a in Triple Transgenic Mice of Alzheimer’s Disease. Eur Rev Med Pharmacol Sci. 2016. In press. (2015最新影響因子: 1.213)7. Yang X, He C, Li J, Chen H, Ma Q, Sui X, Tian S, Ying M, Zhang Q, Luo Y, Zhuang Z, Liu J*. Uptake of silica nanoparticles: neurotoxicity and Alzheimer-like pathology in human SK-N-SH and mouse neuro2a neuroblastoma cells. Toxicol Lett. 2014 229(1):240-249. [PMID: 24831964]. (2015最新影響因子: 3.262)8. Yang X, Liu J*, He H, Zhou L, Gong C, Wang X, Yang L, Yuan J, Huang H, He L, Zhang B, Zhuang Z. SiO2 nanoparticles induce cytotoxicity and protein expression alteration in HaCaT cells. Part Fibre Toxicol. 2010 19 7(1):1. [PMID: 20180970]. (2015最新影響因子: 7.113 引用次數(shù): 62)9. Yang Y#, Yang XF# (共同第一作者), Wang YP, Tian Q, Wang XC, Li HL, Wang Q and Wang JZ*. Inhibition of protein phosphatases induces transport deficits and axonopathy. J Neurochem. 2007 102(3): 878-886. [PMID: 17472709]. (2015最新影響因子: 4.281) 10. Zhang C*, #, Yang X# (共同第一作者), Li L, Sui X, Tian Q, Wei W, Wang J, Liu G*. Hypoxia induced tau phosphorylation and memory deficit in rats. Neurodegener Dis. 2014 14(3):107-116. [PMID: 24993525]. (2015最新影響因子: 3.511) 11. Yang XF, Yang Y, Fu ZQ, Li Y, Feng J, Luo JZ, Zhang QY, Wang Q and Tian Q*. Melatonin ameliorates Alzheimer-like pathological changes and spatial memory retention impairment induced by calyculin A. J Psychopharmacol. 2011 25(8):1118-25. [PMID: 20542922]. (2015最新影響因子: 3.593)12. Ren X#, Yang X# (共同第一作者), Hong WX#, Huang P, Wang Y, Liu W, Ye J, Huang H, Huang X, Shen L, Yang L, Zhuang Z, Liu J* . Identification of the proteins related to SET-mediated hepatic cytotoxicity of trichloroethylene by proteomic analysis. Toxicol Lett. 2014. 227(1):12-19. [PMID: 24631019]. (2015最新影響因子: 3.262)13. Yang X, Jiang Y, Li J, Hong WX, Wu D, Huang X, Huang H, Zhou L, Yang L, Yuan J, Zhuang Z, Liu J*. Lentivirus-mediated silencing of I2PP2A through RNA interference attenuates trichloroethylene-induced cytotoxicity in human hepatic L-02 cells. Toxicol Lett. 2012. 209(3):232-238. [PMID: 22245669]. (2015最新影響因子: 3.262) 14. Yang X, Shen Z, Zhang B, Yang J, Hong WX, Zhuang Z, Liu J*. Silica nanoparticles capture atmospheric lead: Implications in the treatment of environmental heavy metal pollution. Chemosphere. 2013 90(2):653-656. [PMID: 23084516]. (2015最新影響因子: 3.340)15. Yang X, Dai G, Li G*, Yang ES. Coenzyme Q10 reduces beta-amyloid plaque in an APP/PS1 transgenic mouse model of Alzheimer's disease. J Mol Neurosci. 2010 41(1):110-113. [PMID: 19834824]. (2015最新影響因子: 2.343 引用次數(shù): 45)16. Yang X, Yang Y, Li G*, Wang J, Yang ES. Coenzyme Q10 attenuates beta-amyloid pathology in the aged transgenic mice with Alzheimer presenilin 1 mutation. J Mol Neurosci. 2008 34(2):165-171. [PMID: 18181031]. (2015最新影響因子: 2.343 引用次數(shù): 44)17. Luo Y#, Yang X# (共同第一作者), Zhao S, Wei C, Yin Y, Liu T, Jiang S, Xie J, Wan X, Mao M, Wu J*. Hydrogen sulfide prevents OGD/R-induced apoptosis via improving mitochondrial dysfunction and suppressing an ROS-mediated caspase-3 pathway in cortical neurons. Neurochem Int. 2013 63(8):826-831. [PMID: 23770272]. (2015最新影響因子: 3.092)18. Luo Y, Liu X, Zheng Q, Wan X, Ouyang S, Yin Y, Sui X, Liu J, Yang X*(通訊作者). Hydrogen sulfide prevents hypoxia-induced apoptosis via inhibition of an H(2)O(2)-activated calcium signaling pathway in mouse hippocampal neurons. Biochem Biophys Res Commun. 2012 425(2):473-477. [PMID: 22846576]. (最新影響因子: 2.297)19. Yang X, Yang Y, Luo Y, Li G*, Wang J, Yang ES. Hyperphosphorylation and accumulation of neurofilament proteins in transgenic mice with Alzheimer presenilin 1 mutation. Cell Mol Neurobiol. 2009 29(4):497-501. [PMID: 19137424]. (2015最新影響因子: 2.506)20. Yang X*(通訊作者), Yang Y, Liu J, Li G, Yang E. Increased phosphorylation of tau and synaptic protein loss in the aged transgenic mice expressing familiar Alzheimer's disease-linked presenilin 1 mutation. Neurochem Res. 2012 37(1):15-22. [PMID: 21842270]. (2015最新影響因子: 2.593)21. Sui X, Ren X, Huang P, Li S, Ma Q, Ying M, Ni J, Liu J*, Yang X*(通訊作者). Proteomic analysis of serum proteins in triple transgenic Alzheimer's disease mice: implications for identifying biomarkers for use to screen potential candidate therapeutic drugs for early Alzheimer's disease. J Alzheimers Dis. 2014 40(3):575-586. [PMID: 24496070]. (2015最新影響因子: 4.151)（被World Medical Frontier（ISSN: 2328-0166）《世界醫(yī)學前沿》收錄為Featured article，詳見http://biomedfrontiers.org/alzheimer-2014-12-17）22. Ma Q, Ying M, Sui X, Huang H, Yang L, Huang X, Zhuang Z, Liu J ,Yang X* (通訊作者). Chronic copper exposure causes spatial memory impairment, selective loss of hippocampal synaptic proteins, and activation of PKR/eIF2α pathway in mice. J Alzheimers Dis. 2015 43(4): 1413-1427. [PMID: 25159668]. (2015最新影響因子: 4.151).23. Yu J, Luo X, Xu H*, Ma Q, Yuan J, Li X, Chang RC, Qu Z, Huang X, Zhuang Z, Liu J, Yang X*(通訊作者). Identification of the key molecules involved in chronic copper exposure-aggravated memory impairment in transgenic mice of Alzheimer's disease using proteomic analysis. J Alzheimers Dis. 2015 44(2):455-469. [PMID: 25352456]. (2015最新影響因子: 4.151).24. Sui X, Liu J, Yang X*(通訊作者). Cerebrospinal fluid biomarkers of Alzheimer’s disease. Neurosci Bull. 2014 30(2): 233-242. [PMID: 24733653]. (2015最新影響因子: 2.509). (Invited review/特邀綜述)25. Du LL, Wang L, Yang XF, Wang P, Li XH, Chai DM, Liu BJ, Cao Y, Xu WQ, Liu R, Tian Q, Wang JZ, Zhou XW. Transient Receptor Potential-canonical 1 is Essential for Environmental Enrichment-Induced Cognitive Enhancement and Neurogenesis. Mol Neurobiol. 2016 Feb 24. [Epub ahead of print]. [PMID: 26910815]. (2015最新影響因子: 5.137)26. Peng Y, Xiong X, Tong X, Li M, Yang X, Hu G, Geng Y, Li J. Correlation of the content of hepatitis B core antigen in peripheral blood mononuclear cells with HBV virus load. Diagn Microbiol Infect Dis. 2015 Sep 30. pii: S0732-8893(15)00351-X. doi: 10.1016/j.diagmicrobio.2015.09.017. [Epub ahead of print]. [PMID: 26680298]. (2015最新影響因子: 2.457)27. Ho YS, Yang X, Yeung SC, Chiu K, Lau CF, Tsang AW, Mak JC, Chang RC*. Cigarette smoking accelerated brain aging and induced pre-Alzheimer-like neuropathology in rats. PLoS One. 2012 7(5):e36752. [PMID: 22606286]. (2015最新影響因子: 3.234)28. Ho YS, Yang X, Lau JC, Hung CH, Wuwongse S, Zhang Q, Wang J, Baum L, So KF, Chang RC*. Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: implication in Alzheimer's disease pathogenesis. J Alzheimers Dis. 2012 28(4):839-854. [PMID: 22101233]. (2015最新影響因子: 4.151)29. Ho YS, Yu MS, Yang XF, So KF, Yuen WH, Chang RC*. Neuroprotective effects of polysaccharides from wolfberry, the fruits of Lycium barbarum, against homocysteine-induced toxicity in rat cortical neurons. J Alzheimers Dis. 2010 19(3):813-827. [PMID: 20157238]. (2015最新影響因子: 4.151 引用次數(shù): 42)30. Li G*, Jack CR, Yang XF, Yang ES. Diet supplement CoQ10 delays brain atrophy in aged transgenic mice with mutations in the amyloid precursor protein: an in vivo volume MRI study. Biofactors. 2008 32(1-4):169-178. [PMID: 19096113]. (2015最新影響因子: 4.592 引用次數(shù): 18) 31. Hong WX, Yang L, Chen M, Yang X, Ren X, Fang S, Ye J, Huang H, Peng C, Zhou L, Huang X, Yang F, Wu D, Zhuang Z, Liu J*. Proteomic analysis of trichloroethylene-induced alterations in expression, distribution, and interactions of SET/TAF-Iα and two SET/TAF-Iα-Binding proteins, eEF1A1 and eEF1A2, in hepatic L-02 cells. Toxicol Appl Pharmacol. 2012 263(2): 259-272. [PMID: 22771849]. (2015最新影響因子: 3.705)32. Hong WX, Liu W, Zhang Y, Huang P, Yang X, Ren X, Ye J, Huang H, Tang H, Zhou G, Huang X, Zhuang Z, Liu J*. Identification of serum biomarkers for occupational medicamentosa-like dermatitis induced by trichloroethylene using mass spectrometry. Toxicol Appl Pharmacol. 2013 273(1):121-129. [PMID: 23994554]. (2015最新影響因子: 3.705)33. Liu J, Liu J, Yuan J, Tao G, Wu D, Yang X, Yang L, Huang H, Zhou L, Xu X, Hu J, Zhuang Z*. Proteome of melamine urinary bladder stones and implication for stone formation. Toxicol Lett. 2012 212（3）:307-314. [PMID: 22688180]. (2015最新影響因子: 3.262) 34. Huang P, Ren X, Huang Z, Yang X, Hong W, Zhang Y, Zhang H, Liu W, Huang H, Huang X, Wu D, Yang L, Tang H, Zhou L, Li X, Liu J*. Serum proteomic analysis reveals potential serum biomarkers for occupational medicamentosa-like dermatitis caused by trichloroethylene. Toxicol Lett. 2014 229(1):101-110. (2015最新影響因子: 3.262) 35. Ke Y*, Lv Z, Yang X, Zhang J, Huang J, Wu S, Li YR. Compensatory effects of hOGG1 for hMTH1 in oxidative DNA damage caused by hydrogen peroxide. Toxicol Lett. 2014, 230(1): 62-68. [PMID: 25127756]. (2015最新影響因子: 3.262)36. Li J, Yang XF, Ren XH, Meng XJ, Huang HY, Zhao QH, Yuan JH, Hong WX, Xia B, Huang XF, Zhou L, Liu JJ, Zou F*. Stable SET knockdown in breast cell carcinoma inhibits cell migration and invasion. Biochem Biophys Res Commun. 2014, 453(9):7-12. [PMID: 25234598]. (2015最新影響因子: 2.297)37. Liu J, Huang P, He Y, Hong WX, Ren X, Yang X, He Y, Wang W, Zhang R, Yang H, Zhao Z, Huang H, Chen L, Zhao D, Xian H, Yang F, Ma D, Yang L, Yin Y, Zhou L, Chen X, Cheng J. Serum amyloid A and clusterin as potential predictive biomarkers for severe hand, foot and mouth disease by 2D-DIGE proteomics analysis. PLoS One. 2014 9(9):e108816. [PMID: 25268271]. (2015最新影響因子: 3.234 引用次數(shù): 12)38. Ho WL, Leung Y, Cheng SS, Lok CK, Ho YS, Baum L, Yang X, Chiu K, Chang RC. Investigating degeneration of the retina in young and aged tau P301L mice. Life Sci. 2015 124:16-23. [PMID: 25592136]. (最新影響因子: 2.702)39. Li G, Liang JM, Li PW, Yao X, Pei PZ, Li W, He QH, Yang X, Chan QC, Cheung PY, Ma QY, Lam SK, Cheng PY, Yang ES*. Physiology and cell biology of acupuncture observed in calcium signaling activated by acoustic shear wave. Pflugers Arch. 2011 462(4):587-597. [PMID: 21796340]. (2015最新影響因子: 4.101 引用次數(shù): 8) (美國有線新聞網(CNN)等媒體報道了這一由香港大學、北京大學、深圳市疾病預防控制中心等機構組成的研究團隊歷經八年的研究成果) 40. Zhang H, Hong WX, Ye J, Yang X, Ren X, Huang A, Yang L, Zhou L, Huang H, Wu D, Huang X, Zhuang Z, Liu J*. Analysis of trichloroethylene-induced global DNA hypomethylation in hepatic L-02 cells by liquid chromatography-electrospray ionization tandem mass spectrometry. Biochem Biophys Res Commun. 2014 446(2):590-595. [PMID: 24632203]. (2015最新影響因子: 2.297)41. Lao W, Fang M*, Yang X. FK506-binding protein 51 (FKBP5) gene polymorphism is not associated with glucocorticoid therapy outcome in patients with idiopathic thrombocytopenic purpura. Mol Med Report. 2012 6(4): 787-790. [PMID: 22825419]. (2015最新影響因子：1.554) 42. Luo Y, Zhou X*, Yang X, Wang J. Homocysteine induces tau hyperphosphorylation in Rats. Neuroreport. 2007 18(18): 2005-2008. [PMID: 18007203]. (2015最新影響因子: 1.520 引用次數(shù): 24)43. Hong WX, Ye JB, Chen MT, Yan Y, Zhou GF, Yang XF, Yang L, Ren XH, Huang HY, Zhou L, Huang XF, Zhuang ZX, Liu JJ*. Trichloroethylene induces biphasic concentration-dependent changes in cell proliferation and the expression of SET-associated proteins in human hepatic L-02 cells. Biomed Environ Sci. 2013 26(7):618-621. [PMID: 23895710] (2015最新影響因子: 1.653 引用次數(shù): 0)44. Lao W, Yang X, Fang M*, Yang X. Polymorphism and expression of macrophage migration inhibitory factor does not contribute to glucocorticoid resistance in idiopathic thrombocytopenic purpura. Pharmazie. 2013 68: 846–849. [PMID: 24273891] (2015最新影響因子: 1.052)45. Zhao XG, Zheng Y, Chan QC, Yang XF, Li G, Yang ES*. Biopsy needle as MRE driver for tumor detection. Conf Proc IEEE Eng Med Biol Soc. 2007 2007:2050-2052. [PMID: 18002389]. (EI indexed)46. Lau CF, Ho YS, Hung CH, Wuwongse S, Poon CH, Chiu K, Yang X, Chu LW, Chang RC*. Protective effects of testosterone on presynaptic terminals against oligomeric β-amyloid peptide in primary culture of hippocampal neurons. Biomed Res Int. 2014 2014:103906. [PMID: 25045655]. (2015最新影響因子: 1.579)47. Liu W, Hong WX, Zhang Y, Huang P, Yang X, Ren X, Huang H, Liu J. Proteomic profiling of occupational medicamentosa-like dermatitis induced by trichloroethylene in serum based on MALDI-TOF MS. Clin Exp Med. 2014 Dec 5. [Epub ahead of print]. [PMID: 25475505]. (2015最新影響因子: 2.959)48. Liu W, Zhou L, Wang H, Zheng B, Wu D, Yang X, Liu J*. CYP2E1 gene rs6413420 polymorphism was first found in the Bouyei ethnic group of China. Int J Clin Exp Med. 2014 7(10):3612-3620. eCollection 2014. [PMID: 25419409]. (2015最新影響因子: 1.277)49. Hong WX, Huang A, Lin S, Yang X, Yang L, Zhou L, Huang H, Wu D, Huang X, Xu H, Liu J. Differential expression profile of membrane proteins in L-02 cells exposed to trichloroethylene. Toxicol Ind Health. 2015 Jun 4. pii: 0748233715588438. [Epub ahead of print] [PMID: 26045551]. (2015最新影響因子: 1.859 引用次數(shù): 0)50. Ren X, Li J, Xia B, Liu W, Yang X, Hong WX, Huang P, Wang Y, Li S, Zou F, Liu J. Phosphoproteomic analyses of L-02 liver cells exposed to trichloroethylene. Toxicol Mech Methods. 2015 May 27:1-8. [Epub ahead of print] [PMID: 26018768]. (2015最新影響因子: 1.517)現(xiàn)任中國毒理學會神經毒理專業(yè)委員會委員，廣東省毒理學會理事，國際阿爾茨海默病協(xié)會會員，深圳市預防醫(yī)學會分子毒理學專業(yè)委員會委員。

[教育背景]
1997/9-2002/6 武漢科技大學，醫(yī)學院，本科/醫(yī)學學士
2002/9-2007/6 華中科技大學，同濟醫(yī)學院，博士（碩博連讀），導師：王建枝教授（期間于2005年-2007年以訪問學者身份赴香港大學醫(yī)學院開展課題合作研究） 以上老師的信息來源于學校網站，如有更新或錯誤，請聯(lián)系我們進行更新或刪除，聯(lián)系方式

南華大學

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