天津科技大學(xué)生物工程學(xué)院導(dǎo)師：滿(mǎn)淑麗 正文

[導(dǎo)師姓名]
滿(mǎn)淑麗

[所屬院校]
天津科技大學(xué)

[基本信息]
導(dǎo)師姓名：滿(mǎn)淑麗
性別：女
人氣指數(shù)：1229
所屬院校：天津科技大學(xué)
所屬院系：生物工程學(xué)院
職稱(chēng)：副教授
導(dǎo)師類(lèi)型：
招生專(zhuān)業(yè)：藥理學(xué)
研究領(lǐng)域：[1]天然產(chǎn)品的提取分離與活性研究；[2]中藥成分鑒定及體內(nèi)代謝研究；[3]中藥組方配伍機(jī)...

[通訊方式]
辦公電話：022-60601265
電子郵件：msl@tust.edu.cn
通訊地址：天津經(jīng)濟(jì)技術(shù)開(kāi)發(fā)區(qū)第十三大街29號(hào)天津科技大學(xué)生物工程學(xué)院

[個(gè)人簡(jiǎn)述]


[科研工作]
長(zhǎng)期從事天然產(chǎn)物成分分離鑒定及活性開(kāi)發(fā)等研究，參與課題多項(xiàng)，其中主持國(guó)家及省部級(jí)項(xiàng)目3項(xiàng)。尤其是對(duì)甾體皂苷類(lèi)成分的鑒定抗腫瘤成藥性作用機(jī)制的闡述安全性等方面開(kāi)展了一系列研究。相關(guān)成果包括作為第一作者或通訊作者發(fā)表SCI論文40余篇；其中一二區(qū)論文20篇，累積影響因子120；目前論文累積引用八百余次，單篇最高引用280次。近五年發(fā)表的主要學(xué)術(shù)論文有：[1]Man SL* Zhang LL Cui JX Yang L Ma L Gao WY*. Curcumin enhances the anti-cancer effects of Paris Saponin II in lung cancer cells. Cell Proliferation. 2018: e12458.[2]Man SL* Chai HY Cui JX Yao JW Ma L Gao WY*. Antitumor and anti-metastatic mechanisms of Rhizoma paridis saponins in Lewis mice. Environmental Toxicology. 2018 33(2): 149-155.[3]Man SL Ma J Yao JW Cui JX Wang CX Li Y Ma L* Lu FP*. Systemic perturbations of key metabolites in Type 2 diabetic rats treated by polyphenols extracts from Litchi chinensis seeds. J Agric Food Chem. 2017 65(35):7698-704[4]Man SL* Li J Qiu PY Liu J Liu Z Ma L Gao WY*. Inhibition of lung cancer in diethylnitrosamine-induced mice by Rhizoma paridis saponins. Molecular Carcinogenesis. 2017 56:1405-13.[5]Man SL Qiu PY Li J Zhang LM Gao WY*. Global metabolic profiling for the study of Rhizoma Paridis Saponins induced hepatotoxicity in rats. Environmental Toxicology. 2017 32:99-108.[6]Qiu PY Sun JC Man SL* Yang H Ma L Yu P Gao WY*. Curcumin attenuates N- nitrosodiethylamine induced liver injury in mice by utilizing the method of metabonomics. J Agric Food Chem. 2017 65 (9) 2000-7.[7]Man SL Li J Liu J Fan W Liu Z Wang JM Gao WY*. Curcumin alleviated the toxic reaction of Rhizoma paridis saponins in a 45-day subchronic toxicological assessment of rats. Environmental Toxicology. 2016 31: 1935-43.[8]Qiu PY Man SL* Yang H Fan W Yu P Gao WY*. Utilization of metabonomics to identify serum biomarkers in murine H22 hepatocarcinoma and deduce antitumor mechanism of Rhizoma Paridis saponins. Chemico-biological interactions. 2016 256: 55-63.[9]Qiu PY Man SL* Li J Liu J Zhang LM Yu P Gao WY*. Overdose Intake of Curcumin Initiates the Unbalanced State of Bodies. J Agric Food Chem. 2016 64: 2765-71.[10]Qiu PY Man SL* Yang H Liu YX Liu Z Ma L Yu P Gao WY*. Metabolic regulatory network alterations reveals different therapeutic effects of cisplatin and Rhizoma paridis saponins in Lewis pulmonary adenoma mice. RSC Advances. 2016 6: 115029 - 38.[11]Liu J Liu Z Man SL* Chai HY Ma L Gao WY*. Inhibition of urethane-induced lung carcinogenesis in mice by Rhizoma paridis saponins involved EGFR/PI3K/Akt pathway. RSC Advances. 2016 6: 92330 - 4.[12]Liu J Man SL* Liu Z Ma L Gao WY*. A synergistic antitumor effect of Polyphyllin I and Formosanin C on hepatocarcinoma cells. Bioorganic & Medicinal Chemistry Letters. 2016 26: 4970-5.[13]Liu J Man SL* Li J Zhang Y Meng X Gao WY*. Inhibition of diethylnitrosamine-induced liver cancer in rats by Rhizoma paridis saponin. Environmental Toxicology and Pharmacology. 2016 46: 103-9.[14]Zhang LL Man SL* Qiu HN Liu Z Zhang M Ma L Gao WY*. Curcumin-cyclodextrin complexes enhanced the anti-cancer effects of curcumin. Environmental Toxicology and Pharmacology. 2016 48: 31-8.[15]Zhang LL Man SL* Wang YS Liu J Liu Z Yu P Gao WY*. Paris Saponin II induced apoptosis via activation of autophagy in human lung cancer cells. Chemico-Biological Interactions. 2016 253: 125-133.[16]Li J Man SL* Qiu PY Fan W Zhang LM Gao WY*. Toxicological risks of Rhizoma Paridis saponins in rats involved NF-κB and Nrf2 signaling. RSC Advances. 2016 6: 31889-31897.[17]Man SL* Ma J Wang CX Li Y Gao WY Lu FP*. Chemical composition and hypoglycaemic effect of polyphenol extracts from Litchi chinensis seeds. J Funct Foods. 2016 22: 313-24.[18]Man SL Li J Fan W Chai HY Liu Z Gao WY*. Inhibition of pulmonary adenoma in diethylnitrosamine-induced rats by Rhizoma paridis saponins. J Steroid Biochem Mol Biol. 2015 154: 62-67.[19]Man SL Chai HY Qiu PY Fan W Liu Z Wang JM Gao WY*. Turmeric enhancing anti-tumor effect of Rhizoma paridis saponins by influencing their metabolic profiling in tumors of H22 hepatocarcinoma mice. Pathol Res Pract. 2015 211: 948-54.[20]Li YY Man SL* Li J Chai HY Fan W Liu Z Gao WY*. The antitumor effect of formosanin C on HepG2 cell as revealed by 1H-NMR based metabolic profiling. Chemico-Biological Interactions. 2014 220C: 193-9.[21]Man SL Fan W Liu Z Gao WY Li YY Zhang LM Liu CX. Antitumor pathway of Rhizoma Paridis Saponins based on the metabolic regulatory network alterations in H22 hepatocarcinoma mice. Steroids. 2014 84:17-21.[22]Man SL Li YY Fan W Gao WY Liu Z Zhang Y Liu CX. Combination therapy of cyclophosphamide and Rhizoma Paridis Saponins on anti-hepatocarcinoma mice and effects on cytochrome p450 enzyme expression. Steroids. 2014 80:1-6.[23]Man SL Fan W Gao WY Li YY Wang Y Liu Z Li HF. Anti-fibrosis and anti-cirrhosis effects of Rhizoma paridis saponins on diethylnitrosamine induced rats. J Ethnopharmacol. 2014 151:407-412.

[教育背景]
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