2022遼寧中醫(yī)藥大學(xué)生藥學(xué),藥學(xué)考研調(diào)劑信息：http://yjszs.lnutcm.edu.cn:7777/ ... a0c1e8f5cfce4b049cf      聯(lián)系方式:    jpleng@126.com

歸國(guó)前擔(dān)任哈佛大學(xué)/麻省理工學(xué)院 nih transformative award 雙聘博士后研究員。擔(dān)任遼寧中醫(yī)藥大學(xué)學(xué)術(shù)委員會(huì)成員，中醫(yī)臟象理論及應(yīng)用教育部重點(diǎn)實(shí)驗(yàn)室、遼寧省中藥現(xiàn)代化重點(diǎn)實(shí)驗(yàn)室成員。同時(shí)擔(dān)任十余本國(guó)際知名學(xué)術(shù)期刊特邀審稿人，完成了一系列國(guó)際級(jí)科技評(píng)審工作。

冷博士在哈佛大學(xué)和麻省理工學(xué)院工作期間指導(dǎo)研究生發(fā)表多篇sci高水平論文，獲得最佳指導(dǎo)教師的評(píng)價(jià)。指導(dǎo)完成的項(xiàng)目獲得多項(xiàng)國(guó)家專利授權(quán)，多項(xiàng)臨床檢測(cè)發(fā)明專利并得到學(xué)術(shù)推廣,獲上海市科技成果獎(jiǎng)勵(lì)。主持的哈佛大學(xué)醫(yī)學(xué)院科技項(xiàng)目，被評(píng)為年度最有價(jià)值的生物醫(yī)學(xué)檢測(cè)方法。實(shí)驗(yàn)室在核酸分子精準(zhǔn)檢測(cè)領(lǐng)域取得國(guó)際同行的認(rèn)可。與哈佛大學(xué)附屬麻省總醫(yī)院、兒童醫(yī)院；復(fù)旦大學(xué)附屬腫瘤醫(yī)院、中山醫(yī)院以及歐美頂尖醫(yī)藥企業(yè)諾華、輝瑞、賽默飛等合作研發(fā)醫(yī)藥檢測(cè)新方法，科研成果得到產(chǎn)業(yè)界頂級(jí)媒體的多次報(bào)道，建立了產(chǎn)、學(xué)、研的良性循環(huán)，形成了研究生實(shí)驗(yàn)室培養(yǎng)，醫(yī)院、生物醫(yī)藥企業(yè)搶人的良好局面。

本實(shí)驗(yàn)室的研究方向?yàn)椋褐嗅t(yī)藥研究新方法開(kāi)發(fā)及應(yīng)用。綜合利用生物分析化學(xué)、系統(tǒng)生物學(xué)等方法研究生命分子如何與暴露物質(zhì)相互作用及相關(guān)疾病的風(fēng)險(xiǎn)評(píng)估，重點(diǎn)針對(duì)組成機(jī)體的重要組成核酸、蛋白質(zhì)、脂質(zhì)開(kāi)展工作，并研究中醫(yī)藥對(duì)于細(xì)胞和組織的修復(fù)行為。哈佛大學(xué)醫(yī)學(xué)院干細(xì)胞研究所主任rich、斯坦福大學(xué)資深生物醫(yī)藥分析教授zare和行業(yè)國(guó)際頂級(jí)期刊的現(xiàn)任主編jonh曾高度評(píng)價(jià)冷博士對(duì)于分析科學(xué)界的貢獻(xiàn)。

冷博士主持國(guó)家級(jí)科研項(xiàng)目和高層次人才項(xiàng)目?jī)身?xiàng)，并作為重要成員參與國(guó)際項(xiàng)目，完成了一系列國(guó)際團(tuán)隊(duì)優(yōu)秀成果。建立了一系列涉及小分子、核酸和蛋白質(zhì)的醫(yī)藥檢測(cè)方法，指導(dǎo)完成的同位素標(biāo)記生物醫(yī)藥分析方法、精準(zhǔn)核酸修飾組學(xué)、精準(zhǔn)蛋白質(zhì)組學(xué)等取得了美國(guó)國(guó)立衛(wèi)生研究院nih和麻省理工學(xué)院mit同行的認(rèn)可與一致好評(píng)。

誠(chéng)摯的歡迎各位研究生同學(xué)加入團(tuán)隊(duì)，共同為祖國(guó)的中醫(yī)藥事業(yè)奮斗！


科研項(xiàng)目及經(jīng)費(fèi)
國(guó)家自然科學(xué)基金，30萬(wàn)主持。

高層次人才啟動(dòng)基金，100萬(wàn)主持。

國(guó)家自然科學(xué)基金，80萬(wàn)主要參加人員

曾作為主要人員參與四項(xiàng)nih重點(diǎn)項(xiàng)目累計(jì)科研經(jīng)費(fèi)800萬(wàn)美元。


成果獎(jiǎng)勵(lì)

上海市科技成果獎(jiǎng)勵(lì)-基于maldi-ms的酶學(xué)生物毒性預(yù)測(cè)分析

2019年參加若干波士頓地區(qū)高等學(xué)校：哈佛大學(xué)和麻省理工學(xué)院生物醫(yī)藥相關(guān)學(xué)術(shù)會(huì)議，取得最佳報(bào)告獎(jiǎng)勵(lì)。

2018年參加美國(guó)nih毒理會(huì)議，發(fā)布學(xué)術(shù)界和行業(yè)企業(yè)家關(guān)心的重要數(shù)據(jù)、項(xiàng)目結(jié)題匯報(bào)，獲得優(yōu)秀。

山東大學(xué)齊魯青年學(xué)者




論文情況
1.          leng, j.; hartwell, h.j.; yu, r.; lai, y.; bodnar, w.m., et al. evaluation of  inhaled low-dose formaldehyde-induced dna adducts and dna-protein cross-links by liquid chromatography-tandem mass spectrometry. archive of toxicology. 93:763-773; 2019 top
2.          leng, j.; wang, y. liquid chromatography-tandem mass spectrometry for the quantification of tobacco-specific nitrosamine-induced dna adducts in mammalian cells. analytical chemistry. 89:9124-9130; 2017  top
3.  wang, p.; leng, j.; wang, y.  dna replication studies of n-nitroso compound-induced o (6)-  alkyl-2'-deoxyguanosine lesions in escherichia coli. j biol chem.  2019:007358; 2019 top
4.   du, h.; leng, j.; wang, p.; li, l.; wang, y.  impact of tobacco-specific nitrosamine-derived dna adducts on the  efficiency and fidelity of dna replication in human cells. j biol chem.  293:11100-11108; 2018 top
5.      guo, s.; leng, j.; tan, y.; price, n.e.; wang, y.   quantification of dna lesions induced by   4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in mammalian cells. chem   res toxicol. 32: 708-717; 2019
6.      zhou, t.; leng, j.;  peng, y.; zhang, l.; guo, y. mass spectrometric analysis of free fatty  acids in infant milk powders by frozen pretreatment coupled with  isotope-labeling derivatization. j sep sci. 39:873-879; 2016
7.      liu, c.w.; tian, x.; hartwell, h.j.; leng, j.;  chi, l.; lu, k., et al. accurate measurement of formaldehyde-induced  dna-protein cross-links by high-resolution orbitrap mass spectrometry. chem res toxicol. 31:350-357; 2018
8.      xue, j.; lai, y.; chi, l.; tu, p.; leng, j.; liu, c.w., et al. serum  metabolomics reveals that gut microbiome perturbation mediates  metabolic disruption induced by arsenic exposure in mice. j proteome  res. 18:1006-1018; 2019
9.      tu, p.; xue, j.; bian, x.; chi, l.; gao, b.; leng, j.,  et al. dietary administration of black raspberries modulates arsenic  biotransformation and reduces urinary 8-oxo-2'-  deoxyguanosine in mice.  toxicol appl pharmacol. 377:114633; 2019
10.      leng, j.;  liu, c.w.; hartwell, h.j.; yu, r.; lai, y., et al. evaluation of  inhaled low dose formaldehyde induced dna damage by liquid  chromatography-tandem mass spectrometry. toxicol. lett. 295:s155-s156; 2018
11.          leng, j.; guan, q.; sun, t.; wang, h.; cui, j.; liu, q., et al. direct infusion electrospray ionization-ion mobility-mass spectrometry for comparative profiling of fatty acids based on stable isotope labeling. anal chim acta. 887:148-154; 2015  q1
12.         leng, j.; wang, h.; zhang, l.; zhang, j.; guo, y. a highly sensitive isotope-coded derivatization method and its application for the mass spectrometric analysis of analytes containing the carboxyl group. anal chim acta. 758:114-121; 2013 q1
13.          leng, j.; guan, q.; sun, t.; wu, y.; cao, y.; guo, y. application of isotope-based carboxy group derivatization in lc-ms/ms analysis of tissue free-fatty acids for thyroid carcinoma. j pharm biomed anal. 84:256-262; 2013
14.          leng, j.; wang, h.; zhang, l.; zhang, j.; cai, t.; yao, j., et al. integration of high accuracy n-terminus identification in peptide sequencing and comparative protein analysis via isothiocyanate-based isotope labeling reagent with esi ion-trap tof ms. j am soc mass spectrom. 22:1204-1213; 2011
15.          leng, j.; zhu, d.; wu, d.; zhu, t.; zhao, n.; guo, y. analysis of the differentially expressedlow molecular weight peptides in human serum via an n-terminal isotope labeling technique combining nano-liquid chromatography/matrix-assisted laser desorption/ionization mass spectrometry. rapid commun mass spectrom. 26:2555-2562; 2012
16.          leng, j.; wang, h.; zhang, l.; zhang, j.; guo, y. application of tandem mass  spectra for the peaks of isotope pattern in the elemental composition assignment of product ions. chin   j chem. 28:1751-1756; 2010
17.      cao, y.; guan, q.; sun, t.; wang, h.; leng, j.; guo, y. n-alkylpyridinium quaternization combined with liquid chromatography-electrospray ionization-tandem mass spectrometry: a highly sensitive method to quantify fatty alcohols in thyroid tissues. anal chim acta. 849:19- 26; 2014 anal chim acta.
18.      wang, h.; zhang, l.; zhang, j.; leng, j.; cai, t.; guo,y.n-alkylpyridinium quaternizationfor assisting electrospray ionization of sterols in oil by quadrupole-time of flight mass spectrometry. j mass spectrom. 48:1101-1108; 2013
19.      wang, h.; zhang, l.; zhang, j.; leng, j.; cai, t.; guo, y. improvement and extension of the application scope for matrix-assisted laser desorption/ionization mass spectrometric analysis- oriented n-alkylpyridinium isotope quaternization. anal chim acta. 707:100-1062011
20.      xue, j.; lai, y.; chi, l.; tu, p.; leng, j.; liu, c.w., et al. serum metabolomics reveals that gut microbiome perturbation mediates metabolic disruption induced by arsenic exposure in mice. j proteome res. 18:1006-1018; 2019
21.      liu, q.; guo, j.; cai, y.; leng, j.; liu, h.; chen, l. preparation and characterization of aminated silica fluorescent microspheres. chemical industry and engineering progress. 7:2130-2134; 2016.
22.      liu, q.; guo, j.; leng, j.; duan, p.; liu, h.; chen, l. preparation and characterization of aminated silica fluorescent microspheres. new chemical materials. 1: 98-100; 2016.