沈陽藥科大學藥學院導師：熊志立 正文

[導師姓名]
熊志立

[所屬院校]
沈陽藥科大學

[基本信息]
導師姓名：熊志立
性別：女
人氣指數(shù)：1213
所屬院校：沈陽藥科大學
所屬院系：藥學院
職稱：副教授
導師類型：碩導
招生專業(yè)：分析化學、藥物分析學、藥學（藥物分析學方向）

[通訊方式]
辦公電話：024-43520571
電子郵件：bearry200@126.com
通訊地址：遼寧省本溪高新技術產業(yè)開發(fā)區(qū)華佗大街26號

[個人簡述]
熊志立，女，教授，博士研究生導師。1996年畢業(yè)于天津醫(yī)科大學藥學院，獲理學學士學位，2003年獲沈陽藥科大學藥學專業(yè)博士學位，畢業(yè)后留校任教，在分析化學教研室工作至今。2005年被聘為沈陽藥科大學藥物分析專業(yè)和分析化學專業(yè)碩士研究生導師，2011年9月作為訪問學者去美國University of Georgia, Athens交流學習1年，2013年5月任分析化學教研室主任。2018年4月被聘為沈陽藥科大學藥物分析專業(yè)博士研究生導師。作為課題負責人主持了國家自然科學基金面上項目1項，國家自然科學基金青年基金項目1項，遼寧省博士啟動基金1項，遼寧省科學技術計劃項目1項，遼寧省高等學校杰出青年學者成長計劃1項，沈陽藥科大學科研專項基金2項；作為項目骨干成員參加國家自然科學基金重點項目1項，面上項目及青年基金項目4項。另外，主持橫向科研項目數(shù)項。目前在國內外核心學術期刊發(fā)表研究論文130余篇，其中以第一作者或通訊作者在Journalof Chromatography B， Journal of Pharmaceutical and Biomedical Analysis，Talanta，Journalof Ethnopharmacology等SCI期刊發(fā)表科研論文20余篇。

[科研工作]
近年來發(fā)表代表性論文(限第一作者或通訊作者，SCI須寫明影響因子)：（限填10篇）1.ZhiliXiong, Yanmin Wang, Lang Lang, Shuping Ma, Longshan Zhao,Wei Xiao, Yanjuan Wang*. Tissue metabolomic profiling to reveal the therapeuticmechanism of reduning injection on LPS-induced acute lung injury rats. Royal Society of Chemistry Advances(RSC Advances).2018, 8, 10023–10031 (SCI, IF=3.108).2.XiaoWu, Yue Huang, Jinghan Sun, Yongqing Wen , Feng Qin, Longshan Zhao, Zhili Xiong* A HILIC-UHPLC-MS/MSuntargeted urinary metabonomics combined with quantitative analysis of fivepolar biomarkers on osteoporosis rats after oral administration of Gushudan.Journal of Chromatography B, 2018,1072: 40-49. (SCI, IF=2.603)3.YunhaiBo, Lijuan Wang, Xiao Wu, Longshan Zhao, Jingyu Yang, Zhili Xiong*, Chunfu Wu. Development and validation of aUHPLC–MS/MS method for the simultaneous determination of five bioactiveflavonoids in rat plasma and comparative pharmacokinetic study after oraladministration of Xiaochaihu Tang and three compatibilities. Journal ofSeparation Science.2017,40(9): 1896–1905.(SCI,IF=2.557)4.Zhili Xiong, Jie Yang, Yue Huanga, KuoZhang,Yunhai Bo, Xiumei Lu, Guangyue Su, Jie Ma, Jingyu Yang,Longshan Zhao,*,Chunfu Wub,* * Serum metabonomics study of anti-depressive effect ofXiao-Chai-Hu-Tang on rat model of chronic unpredictable mild stress. Journal ofChromatography B.2016, 1029–1030: 28–35. (SCI, IF=2.687)5.Qin Feng, Yin Bincan, Wang Lijuan, Li Kunjie, Li Famei, Xiong Zhili*. Quantification oftrantinterol, its two metabolites and their primary conjugated metabolites inhuman plasma by ultra-high-performance liquid chromatography- tandem mass spectrometryand its application to a pharmacokinetic study. Journal of pharmaceutical andbiomedical analysis, 2016,117:413-418 (SCI, IF=3.255)6.Yue Huang, Yunhai Bo,Xiao Wu, Qiuyi Wang, Feng Qin, Longshan Zhao, Zhili Xiong*. An integrated serum and urinary metabonomic researchbased on UPLC-MS and therapeutic effects of Gushudan onprednisolone-inducedosteoporosis rats. Journal of Chromatography B. 2016, 1027:119-130. (SCI,IF=2.687)7.Chengying Wang, HongSun, Shaojie Wang, Zhonggui He, Longshan Zhao, Zhili Xiong*, Feng Qin** Development and validation of a chiral liquid chromatography method for thedetermination of MP 3950 enantiomers, a high selective 5-HT4 receptor agonist,in rat plasma and its application to stereoselectivepharmacokinetic study. Journal of Chromatography B. 2016, 1033: 49–54. (SCI, IF=2.687)8.Longshan Zhao, Zhili Xiong*,Xiumei Lu, Shuning Zheng, Fang Wang, Lin Ge, Guangyue Su, Jingyu Yang, ChunfuWu**. Metabonomic evaluation of chronic unpredictable mild stress-inducedchanges in rats by intervention of fluoxetine by HILIC-UHPLC/MS. Pos One,10(6), p e0129146. (SCI, IF=3.234)9.Yuejuan Lu, Ning Li, Ying Deng, Longshan Zhao, Xingjie Guo, Famei Li, Zhili Xiong*. Simultaneousdetermination of icariin, naringin and osthole in rat plasma by UPLC-MS/MS andits application for pharmacokinetic study after oral administration of Gushudancapsules. Journal of Chromatography B. 2015(993-994):75-80. (SCI, IF=2.729)10.Xinyu Liu, Shangshang Zhang, Xiumei Lu, Shuning Zheng, Famei Li, Zhili Xiong*. Metabonomicstudy on the anti-osteoporosiseffect of RhizomaDrynariae and its action mechanism using ultra-performanceliquid chromatography-tandem mass spectrometry. Journal of Ethnopharmacology2012, 139(1):311-317. (SCI, IF=3.097)

[教育背景]

沈陽藥科大學

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