四川大學(xué)生命科學(xué)學(xué)院導(dǎo)師：張渝君 正文

　　
　　姓名：張渝君　性別：女
　　職稱：教授　學(xué)院：生命科學(xué)學(xué)院
　　研究方向：
　　免疫化學(xué)誘導(dǎo)蛋白MCP-1（CCL2）與肝臟疾病的關(guān)系及其在肝癌治療方面的研究；T淋巴細(xì)胞白血病發(fā)生機(jī)理的研究。
　　電話：028-85418843
　　Email：yz5357@gmail.com

　　簡歷：
　　·1978, 2-1982, 2 畢業(yè)于四川大學(xué)生物系生物化學(xué)專業(yè)獲理學(xué)學(xué)士學(xué)位
　　·1982, 2-1985, 2 畢業(yè)于四川大學(xué)生物系生物化學(xué)專業(yè)獲理學(xué)碩士學(xué)位
　　·1985, 2-1987, 2 四川大學(xué)生物系遺傳學(xué)專業(yè)助教
　　·1987, 2-1992, 2 畢業(yè)于美國馬薩諸塞大學(xué)細(xì)胞與發(fā)育生物學(xué)專業(yè)獲理學(xué)博士學(xué)位
　　·1992, 2-1996, 5 在美國哈佛大學(xué)醫(yī)學(xué)院Dana-Farber癌癥中心作博士后研究
　　·1996, 5-2001, 5 任波士頓大學(xué)醫(yī)學(xué)院醫(yī)學(xué)系講師
　　·2001, 5-2008, 5 任波士頓大學(xué)醫(yī)學(xué)院醫(yī)學(xué)系助理教授
　　·2008, 5-2010, 4 任波士頓大學(xué)醫(yī)學(xué)院醫(yī)學(xué)系副教授
　　·2010, 4- 現(xiàn)在 任四川大學(xué)生命科學(xué)學(xué)院特聘教授

　　研究內(nèi)容：
　　·研究在肝癌細(xì)胞中, MCP-1（CCL2）的表達(dá)是如何被調(diào)控的，有哪些信號(hào)傳導(dǎo)通路參與
　　MCP-1（CCL2）表達(dá)的調(diào)控。
　　·研究MCP-1（CCL2）與免疫反應(yīng)的關(guān)系以及誘導(dǎo)肝癌細(xì)胞凋亡的分子機(jī)理。
　　·篩選MCP-1（CCL2）的抑制劑和拮抗劑, 研究其對肝癌細(xì)胞生長的抑制作用和機(jī)理。
　　·研究由于白介素16前體蛋白-p80缺失誘導(dǎo)T淋巴細(xì)胞白血病發(fā)生的機(jī)理。

　　發(fā)表論文：
　　·Zhang, Y., and Kunkel, J.G. (1992). Modulation of F-actin filaments organization during morphogenesis of insect follicle cell epithelium. Tissue & Cell 24:905-17.
　　·Zhang, Y., and Kunkel, J.G. (1993). Most egg calmodulin is a follicle cell contribution to the cytoplasm of the oocyte. Dev. Biol. 161:513-21.
　　·Zhang, Y., Rutledge, B.J. and Rollins, B.J. (1994). Structure/activity analysis of human monocyte chemoattractant protein-1 (MCP-1): identification of a mutated protein that inhibits MCP-1 mediated monocyte chemotaxis. J Biol Chem. 269:15918-24.
　　· Ernst, C.A., Zhang, Y., Hancock, P.R., Rutledge, B.J., Corless, C.L. and Rollins, B.J. (1994). Biochemical and biological characterization of murine MCP-1: identification of two functional domains. J. Immunol. 152:2541-9.
　　·Zhang, Y., and Rollins, B.J. (1995). A dominant negative inhibitor indicates that monocyte chemoattractant protein-1 functions as a dimer. Mol. Cell Biol. 15:4851-4855.
　　·Zhang, Y., Ernst, C.A., Rollins, B.J. (1996). Structure/Activity Analysis. Methods 10:93-10.
　　·Schecter, A.D., Rollins, B.J., Zhang, Y., Charo, I.F., Fallon, J.T., Rossikhina, M. Giesen, P.L.A., Nemerson, Y., and Taubman, M.B. (1997) Tissue factor is induced by monocyte chemoattractant protein-1 in human aortic smooth muscle and THP-1 cells. J. Biol. Chem. 272:28568-28573.
　　·Yen, H., Zhang, Y., Penfold, S., and Rollins, B.J. (1997) MCP-1-mediated chemotaxis requires activation of non-overlapping signal transduction pathways. J. Leukocyte Biol. 61:529-532.
　　·Zhang, Y., Center, D.M., Wu, D.M.H., Cruikshank, W.W., Yuang, J., Andrews, D.W. and Kornfeld, H. (1998). Processing and Activation of pro-IL-16 by caspase 3.
　　J Biol Chem. 273:1144-1149.
　　·Keane, J., Nicoll, J., Kim, S., Wu, D.M.H. Cruikshank, W.W., Brazer, W., Natke, B., Zhang, Y., Center, D.M., and Kornfeld, H. (1998) Conservation of Structure and Function Between Human and Murine IL-16. J. Immunol. 160:5945-5954.
　　·Wu, D.M.HJ., Zhang, Y., Parada, N.A., Kornfeld, H., Nicoll, J., Center, D.M., and Cruikshank, W.W. (1999) Processing and Release of IL-16 from CD4+ But Not CD8+ T Cells Is Activation Dependent. J. Immunol. 162:1287-1293.
　　·Zhang, Y., Kornfeld, H., Cruikshank, W.W., Kim, S., Reardon, C.C., and Center, D.M.. (2001) Nuclear Translocation of the N-terminal Pro-domain of Interleukin-16. J. Biol. Chem. 276:1299-1303.
　　·Wilson, K.C., Cruikshank, W.W., Center, D.M., and Zhang, Y.. (2002). The N-terminal Domain of Prointerleukin-16 Contains a Functional CcN Motif. Biochemistry. 41: 14306-14312.
　　· Wilson, K.C., Cruikshank, W.W., Center, D.M., and Zhang, Y.. (2003). HTLV-1 Tax Oncoprotein Binds to the Precursor of Interleukin-16: a PDZ-Containing Protein. Virology 306: 60-67.
　　·Center, D.M., Cruikshank, W.W., Zhang,Y.. (2004). Nuclear Pro-IL-16 Regulation of T cell Proliferation: p27KIP1-Dependent G0/G1 Arrest Mediated by Inhibition of Skp2 Transcription. J. Immunol. 172 (3):1654-1660.
　　·Chang, D.L., Qiu, W., Ying, H., Zhang, Y., Chen, C.Y., and Xiao, Z.X.. (2007). ARF Promotes Accumulation of Retinoblastoma Protein through Inhibition of MDM2. Oncogene 26:4627-4634.
　　·Zhang, Y., Tuzova, M., Xiao, Z.X., Cruikshank, W.W., and Center, D.M.. (2008). Pro-Interleukin-16 recruits Histone Deacetylase 3 to the Skp2 Core Promoter through Interaction with Transcription Factor GABP. J. Immunol. 180:402-408.
　　·Qiu, W., Wu, J., Walsh, W. M., Zhang, Y., Chanr, C-Y., Fujita, J., and Xiao ZX. (2008). Retinoblastoma protein modulates gankyri-MDM2 in regulation of p53 stability and chemosensitivity in cancer cells. Oncogene 27:4034-4043.

　　專利：
　　·Rollins,B.J. and Zhang,Y.，“Human monocyte chemottractant protein-1 (MCP-1) derivatives” (US Patent Number: 5,459,128)。
　　·Rollins,B.J. and Zhang,Y. Chemokine N-Terminal Deletion Mutations (US Patent Number: 5,739,103).

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