山東大學(xué)生命科學(xué)學(xué)院導(dǎo)師：石德利 正文

　　石德利 教授
　　博士生導(dǎo)師
　　0531-88364935
　　dshi@sdu.edu.cn
　　
　　教育背景
　　1978年-1982年：山東大學(xué)生物學(xué)系動物胚胎學(xué)專業(yè)學(xué)生，1982年獲得學(xué)士學(xué)位。
　　1983年-1988年：在法國巴黎第六大學(xué)博士研究生，發(fā)育生物學(xué)專業(yè)，1988年獲得博士學(xué)位。
　　1988年-1989年：在法國原子能中心作博士后研究。
　　1989年-1997年：任法國國家科學(xué)研究中心研究員。
　　1998-至今：任法國國家科學(xué)研究中心主任研究員。
　　2006-至今：任山東大學(xué)講座教授。
　　
　　研究方向
　　多年來一直從事發(fā)育生物學(xué)研究. 利用兩棲類(非洲爪蟾)和斑馬魚胚胎為動物模式,對動物胚胎發(fā)育過程中的信號傳遞通路和基因功能，調(diào)控機(jī)理用分子生物學(xué),細(xì)胞生物學(xué),生物化學(xué)和生物物理學(xué)等手段和實驗工具進(jìn)行跨學(xué)科的研究。特別是通過對Wnt信號通路的結(jié)構(gòu)和功能研究來篩選對治療和預(yù)防腫瘤發(fā)生的化學(xué)藥物在國際領(lǐng)先。另一個研究方向集中在人類遺傳疾病相關(guān)基因在胚胎發(fā)育中的功能和作用機(jī)理，為人類遺傳疾病的致病機(jī)理提供重要的理論基礎(chǔ)。
　　
　　研究成果及發(fā)表論文
　　多幾年來在研究胚胎發(fā)育機(jī)制及研究信號通路機(jī)理等領(lǐng)域取得令國際同行公認(rèn)的成果,并有廣泛的國際合作。在Development, Molecular Cell, EMBO J, Developmental Biology等影響因子高的發(fā)育生物學(xué)和分子生物學(xué)國際權(quán)威雜志上已發(fā)表論文近６０余篇。累計被引用
　　超過１５００次，部分論文的單篇引用次數(shù)超過160次。個人Ｈ因子達(dá)到２２。
　　1）Li, H. Y., Bourdelas, A., Carron, C. and Shi, D. L. (2010). The RNA binding protein Seb4/RBM24 is a target of MyoD and is required for myogenesis during Xenopus early development. Mech. Dev. 127, 281-291.
　　2) Lee，H. J., Finkelstein, D., Li, X., Wu, D., Shi, D. L., Zheng, J. J. （2011）. Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein. J Biol Chem. [Epub ahead of print].
　　3）Lee, H. J., Wang, N.X., Shi, D. L. and Zheng, J. J.（2009）. Sulindac inhibits canonical Wnt signaling by blocking the PDZ domain of the protein Dishevelled. Angew Chem Int Ed Engl. 48(35):6448-52
　　4) Shao, M., Liu, Z. Z., Wang, C. D., Li, H. Y., Carron, C., Zhang, H. W. and Shi, D. L. (2009). Down syndrome critical region protein 5 regulates membrane localization of Wnt receptors and Dishevelled stability and convergent extension
　　in vertebrate embryos. Development 136，2121-2131.
　　5）Grandy， D., Shan, J., Zhang, X., Rao, S., Akunuru, S., Li, H., Zheng, Y., Alpatov, I., Zhang, X. A., Lang, R., Shi, D. L. and Zheng, J.J. (2009). Discovery and characterization of a small molecule inhibitor of the PDZ domain of
　　dishevelled. J Biol Chem. 284(24):16256-63
　　6）Bourdelas, A., Li, H. Y., Carron, C. and Shi, D. L. (2009). Dynamic expression of distinct genes in presomitic and somitic mesoderm during Xenopus early development. Intl J. Dev. Biol. 53(7):1075-9.
　　7）Coolen, M., Sauka-Spengler, T., Nicolle, D., Le-Mentec, C., Lallemand, Y., Da Silva, C., Plouhinec, J. L., Robert, B., Wincker, P., Shi, D. L.and Mazan, S. (2007). Evolution of axis specification mechanisms in jawed vertebrates:
　　insights from a chondrichthyan. PLoS ONE. 2(4):e374.
　　8）Havis, E., Le Mevel, S., Morvan, D. G., Shi, D. L., Scanlan, T. S., Demeneix, B. A. and Sachs, L. M. (2006). Unliganded thyroid hormone receptor is essential for Xenopus laevis eye development. EMBO J. 25, 4943-4951.
　　9）Li, X. Y., Zhang, W., Chen, D. Y., Lin, Y. S., Huang, X. W., Shi, D. L. and Zhang, H. W. (2005). Expression of a novel somite formation related-gene, AmphiSom, during amphioxus development. Dev. Genes Evo. 216, 52-55.
　　10）Li, H. Y., Bourdelas, A., Carron, C., Gomez, C., Boucaut, J. C. and Shi, D. L. (2006). FGF8, Wnt8 and Myf5 are target genes of Tbx6 during anteroposterior patterning and myogenesis in Xenopus embryo. Dev. Biol. 290(2):470-481.
　　11）Della Gaspera, B., Sequeira, I., Charbonnier, F., Becker, C., Shi, D. L. and Chanoine, C. (2005). Spatio-temporal expression of MRF4 transcripts and protein during Xenopus laevis embryogenesis. Dev Dyn. 235, 524-529.
　　12）Shan, J. F., Wang, J. M., Shi, D. L. and Zheng, J. (2005). Identification of non-peptide inhibitor of the Dishevelled PDZ domaine. Biochemistry 44, 15495-15503.
　　13）Carron, C., Bourdelas, A., Li, H. Y., Boucaut, J. C. and Shi, D. L. (2005). Antagonistic interaction between IGF and Wnt/JNK signalings in convergent extension in Xenopus embryo. Mech. Dev. 122, 1234-1247.
　　14）Plouhinec, J. L., Granier, C., Le Mentec, C., Lawson, K. A., Sabéran-Djoneidi, D., Aghion, J., Shi, D .L., Collignon, J. and Mazan, S. (2004). Identification of the mammalian Not gene via a phylogenomic approach. Gene Expr. Patterns
　　5/1, 11-22.
　　15). Cohen-Tannoudji, J, Counis, R., Herve, D, Shi, D. L. and Verge, D. (2004). International symposium on G Protein-Coupled Receptors. Biol. Cell 96, 395-397.
　　16). Cohen-Tannoudji, J., Counis, R, Herve, D, Shi, D. L. and Verge, D. (2004). G Protein-Coupled Receptors: New insights into signaling and regulation. Biol. Cell 96, 325-326.
　　17）Roman-Roman, S., Shi, D.L, Stiot, V., Hay, E., Vassiere, B., Garcia, T., Baron, R. and Rawadi, G. (2004). -cateninbMurine Frizzled-1 behaves as an antagonist of the canonical Wnt/ signaling. J. Biol. Chem. 279, 5725-5733.
　　18）Bourdelas, A., Li, H. Y., Boucaut, J. C. and Shi D. L. (2004). Identification of distinct genes with restricted expression in the somitic mesoderm of Xenopus embryo. Gene Expr. Patterns 4/6, 695-699.
　　19) Shi D. L. (2003). Wnt signaling and the regulation of gastrulation movements. In "The Vertebrate Organizer" (ed: Grunz). Springer-Verlag, vol 46, pp187-200.
　　20）Wong, H. C., Bourdelas, A., Shao, Y. M., Wu, D. Q., Shi, D. L. and Zheng, J. (2003). Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Mol. Cell 12, 1251-1260.
　　21）Carron, C. Pascal, A., Djiane, A., Boucaut, J.C., Shi, D.L. and Umbhauer, M. (2003). Frizzled receptor dimerization is -catenin pathway.bsufficient to activate the Wnt/ J. Cell Sci. 116, 2541-2550.
　　22）Shi, D. L., Bourdelas, A., Umbhauer, M. and Boucaut, J. C. (2002). Zygotic Wnt/?-catenin signaling preferentially regulates the expression of Myf5 gene in the mesoderm of Xenopus. Dev. Biol. 245, 124-135.
　　23) Sauka-Spengler, T., Germot, A., Shi, D. L. and Mazan, S. (2002). Expression patterns of an Otx2 and an Otx5 orthologue in the urodele pleurodeles waltl : Implications on the evolutionary relationships between the balancers and cement
　　gland in amphibians. Dev. Genes Evol. 212, 380-387.
　　24) Sauka-Spengler, T, Baratte, B, Shi, D. L. and Mazan, S. (2001). Structure and expression of an Otx5-related gene in the dogfish Scyliorhinus canicula: evidence for a conserved role of Otx5 and Crx genes in the specification of
　　photoreceptors. Dev. Genes Evol. 211, 533-544.
　　25）Umbhauer, M., Boucaut, J. C. and Shi, D. L. (2001). Repression of XMyoD expression and myogenesis by Xhairy-1 in Xenopus early embryo. Mech. Dev. 109, 61-68.
　　26）Djiane, A., Riou, J. F., Umbhauer, M., Boucaut, J. C. and Shi, D. L.(2000). Role of frizzled 7 in the regulation of convergent extension movements during gastrulation in Xenopus laevis. Development 127, 3091-3100.
　　27）Umbhauer, M., Djiane, A., Goisset, C., Penzo, A., Riou, J. F., Boucaut, J. C. and Shi, D. L. (2000). The C-terminal cytoplasmic K-T-X-X-X-W motif in frizzled receptors mediates Wnt/?-catenin signalling. EMBO J. 19, 4944-4954.
　　28）Shi, D. L. and Boucaut, J.C. (2000). Xenopus frizzled 4 is a maternal mRNA and its zygotic expression is localized to the neuroectoderm and trunk lateral plate mesoderm. Mech. Dev. 93, 243-245.

　　*如果發(fā)現(xiàn)導(dǎo)師信息存在錯誤或者偏差，歡迎隨時與我們聯(lián)系，以便進(jìn)行更新完善。

添加山東大學(xué)學(xué)姐微信，或微信搜索公眾號“考研派小站”，關(guān)注[考研派小站]微信公眾號，在考研派小站微信號輸入[山東大學(xué)考研分?jǐn)?shù)線、山東大學(xué)報錄比、山東大學(xué)考研群、山東大學(xué)學(xué)姐微信、山東大學(xué)考研真題、山東大學(xué)專業(yè)目錄、山東大學(xué)排名、山東大學(xué)保研、山東大學(xué)公眾號、山東大學(xué)研究生招生）]即可在手機(jī)上查看相對應(yīng)山東大學(xué)考研信息或資源。

山東大學(xué)