山東理工大學(xué)生命科學(xué)學(xué)院導(dǎo)師趙博生

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山東理工大學(xué)生命科學(xué)學(xué)院導(dǎo)師趙博生

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山東理工大學(xué)生命科學(xué)學(xué)院導(dǎo)師趙博生 正文


  趙博生
  男,1962年出生,山東青州人,中共黨員,博士,教授,碩士研究生導(dǎo)師。
  全國(guó)先進(jìn)工作者,山東省細(xì)胞生物學(xué)會(huì)常務(wù)理事,,Journal of Biomolecular Structure &Dynamics、Molecular Biology Reports、生命科學(xué)、遺傳等國(guó)內(nèi)外雜志審稿人,淄博市和山東理工大學(xué)高層次人才。
  1983年畢業(yè)于山東曲阜師范大學(xué)生物系,獲學(xué)士學(xué)位,1990年和1994年曾分別到山東師范大學(xué)和北京大學(xué)進(jìn)修學(xué)習(xí)。2006年6月畢業(yè)于中國(guó)海洋大學(xué)海洋生物學(xué)專業(yè),獲理學(xué)博士學(xué)位?,F(xiàn)任山東理工大學(xué)生命科學(xué)學(xué)院院長(zhǎng)、教授委員會(huì)主任。
  主要從事發(fā)育與進(jìn)化生物學(xué)的研究,在模式生物渦蟲、文昌魚發(fā)育、再生過(guò)程中相關(guān)基因的表達(dá)和功能以及相關(guān)蛋白質(zhì)的性質(zhì)分析等研究方向上開展了多年的研究工作,曾主持國(guó)家"973"計(jì)劃項(xiàng)目子課題1項(xiàng)、教育部重點(diǎn)研究項(xiàng)目1項(xiàng),山東省自然科學(xué)基金項(xiàng)目1項(xiàng),參與國(guó)家"863"計(jì)劃1項(xiàng)、國(guó)家基金項(xiàng)目3項(xiàng),發(fā)表論文50余篇,其中SCI源期刊發(fā)表20余篇。曾獲得山東省科技進(jìn)步三等獎(jiǎng),2007年獲山東省自然科學(xué)獎(jiǎng)一等獎(jiǎng)。主講本科生《發(fā)育生物學(xué)》、《現(xiàn)代生物學(xué)進(jìn)展》等課程,負(fù)責(zé)《細(xì)胞生物學(xué)》課程建設(shè),主講研究生《分子發(fā)育生物學(xué)》課程,曾獲曾憲梓優(yōu)秀教師獎(jiǎng)三等獎(jiǎng)、山東省優(yōu)秀教學(xué)成果三等獎(jiǎng),學(xué)校優(yōu)秀教學(xué)成果一等獎(jiǎng)、學(xué)校教學(xué)優(yōu)秀獎(jiǎng)和教學(xué)質(zhì)量獎(jiǎng),指導(dǎo)的本科生畢業(yè)論文獲山東省優(yōu)秀學(xué)士學(xué)位論文。
  2004年以來(lái)共指導(dǎo)碩士研究生16人,畢業(yè)12人,在讀碩士研究生4人,作為副導(dǎo)師指導(dǎo)博士研究生1人。
  近期發(fā)表的主要學(xué)術(shù)論文(*為通訊作者)  
  1. Juan Dong, Ming Xin, Hong Liu, Meng Zhang, Qiuxiang Pang, Lingling Chen, Bosheng Zhao*. Identification, expression of a glycoprotein hormone receptor homolog in the amphioxus Branchiostoma belcheri with implications for origin of vertebrate GpHRs. General and Comparative Endocrinology. 2013, 184: 35-41
  2. Zuoqing Yuan, Mingyue Zheng, Jianyong Zhang, Suzhou Zhao, Lei Guo, Bosheng Zhao*. Effects of anionic surfactants sodium dodecyl sulphate on regeneration and antioxidant enzymes response of planarian Dugesia japonica. Fresenius Enviromental Bulletin.2013, 22:157-162
  3. Luming Zhou, Suge Wu, Dianchen Liu, Bo Xu, Xiufang Zhang, Bosheng Zhao*. Characterization and expression analysis of a trypsin-like serine protease from planarians Dugesia japonica. Molecular Biology Reports. 2012, 39:7041-7047
  4. Qiuxiang Pang, Xuemei Liu, Bosheng Zhao*, Wei Wei, Xiufang Zhang, Lianfei Zhao, Jingjing Xue, Huanhuan Sun. Purification, characterization and induction of C-type lectin in the freshwater planarian Dugesia japonica. Central European Journal of Biology. 2012, 7(2):354-361
  5. Qiuxiang, Pang, Xuemei Liu, Bosheng Zhao*, Huanhuan Sun. Induction of phenoloxidase and other immunological activities in the humoral fluids of amphioxus Branchiostoma belcheri challenged with Lipopolysaccharide (LPS). Fish Physiology and Biochemistry. 2012, 38: 1835-1842
  6. Zuoqing Yuan, Bosheng Zhao*, Jianyong Zhang. Expression Patterns of Stag gene in intact and regenerating planarians Dugesia japonica. Genetics and Molecular Research. 2011, 10(1): 410-418
  7. Zuoqing Yuan, Bosheng Zhao*, Feilong Meng. Toxcity and behavioral effects of anionic surfactant sodium dodecyl sulphate to planarian Dugesia japonica. Fresenius Enviromental Bulletin. 2011, 20(2a):506-510
  8. Xiufang Zhang, Jinxuan Shi, Tongmin Wu, Yaxin Zhang, Shengcheng Lin, Yanming Tao and Bosheng Zhao*. Effect of cadmium on three antioxidant enzyme activities and lipid peroxidation in planarian (Dugesia japonica). Fresenius Enviromental Bulletin. 2011, 20(11): 2920-2926
  9.. Min Liu, Junli Pan, Hongfang Ji, Bosheng Zhao, Shicui Zhang. Vitellogenin mediates phagocytosis through interaction with FcγR. Molecular Immunology. 2011, 49:211-218
  10. Zuoqing Yuan, Bosheng Zhao*, Jianyong Zhang, Shicui Zhang. Characterization and Expression of DjPreb Gene in the Planarian Dugesia japonica. Molecular Biology, 2010, 44(1): 8–13
  11.. Zuoqing Yuan, Bosheng Zhao*, Jianyong Zhang, Shicui Zhang. Expression pattern of DjPreb gene during the planarian Dugesia japonica embryonic development. Molecular Biology, 2010, 44(4): 571-576
  12.. Xiufang Zhang, Bosheng Zhao*, Qiuxiang Pang, Hongyang Yi, Mingxing Xue, Bowen Zhang. Toxicity and behavioral effects of cadmium in planarian (Dugesia japonica Ichikawa et kawakatsu). Fresenius Enviromental Bulletin. 2010, 19(12): 2895-2900
  13. Qiuxiang Pang, Shicui Zhang, Bosheng Zhao. Immune parameters in the humoral fluids of amphioxus Branchiostoma belcheri challenged with Vibrio alginolyticus. Fish & Shellfish Immunology. 2010; 28: 232-234.
  14.. Qiuxiang Pang, Xuemei Liu, Bosheng Zhao, Yongsheng Jiang, Feng Su, Xiufang Zhang, Min Nie, Meng Zhang, Huanhuan Sun. Detection and characterization of phenoloxidase in the freshwater planarian Dugesia japonica. Comparative Biochemistry and Physiology, Part B. 2010; 157: 54-58.
  15. Jingnan Zhao, Yuan Wang, Bosheng Zhao*, Lingling Chen. Analyzing S-Adenosylhomocysteine Hydrolase Gene Sequences in Deuterostome Genomes. Journal of Biomolecular Structure & Dynamics. 2009, 27(3): 371-380
  16. Shaohui Wang, Shicui Zhang, Bosheng Zhao, Limin Lun. Up-regulation of C/EBP by thyroid hormones: A case demonstrating the vertebrate-like thyroid hormone signaling pathway in amphioxus. Molecular and Cellular Endocrinology. 2009, 313: 57-63
  17. Qiuxiang Pang, Shicui Zhang, Bosheng Zhao. Induction of phenoloxidases in the humoral fluids of amphioxus Branchiostoma belcheri by Vibrio alginolyticus and Escherichia coli. Fish & Shellfish Immunology. 2009; 26: 669-671.
  18. Shaohui Wang, Bosheng Zhao*, Shicui Zhang, Hongfang Ji. Cloning, expression, purification and characterization of AmphiTip30, a member of short-chain dehydrogenases/reductases family from the amphioxus Branchiostoma belcheri tsingtauense. Protein Expression and Purification. 2008, 57(1):63-71
  19. Yuan Wang, Bosheng Zhao*, Shicui Zhang, Xiaojuan Qu. Characterization, expression and localization of S-adenosylhomocysteine hydrolase from amphioxus Branchiostoma belcheri tsingtaunese. Bioscience Reports. 2008, 28: 135-144
  20. Yongjun Wang, Bosheng Zhao, Fei Ding, Xiaoxia Jiang, Gut-specific expression of cathepsin L and B in amphioxus Branchiostoma belcheri tsingtauense larvae. European Journal of cell biology. 2008,87:185-193
  21. Yanan He, Bo Tang, Shicui Zhang, Zhenhui Liu, Bosheng Zhao, Lingling Chen. Molecular and immunochemical demonstration of a novel member of Bf/C2 homolog in amphioxus Branchiostoma belcheri: Implications for involvement of hepatic caecum in acute phase response. Fish and Shellfish Immunology. 2008,24(6):768-778
  22. Bosheng Zhao, Shicui Zhang, Yongjun Wang, Zhenhui Liu, Dexin Kong,Characterization and expression of p23 gene in the amphioxus Branchiostoma belcheri. Comparative Biochemistry and physiology part B. 2006, 145: 10-15
  23. Zhao Bosheng, Zhang Shicui, Pang Qiuxiang, Liu Zhenhui, Liang Yujun. Expression, purification and polyclonal antibody generation of p23, an Hsp90 cochaperone, in the amphioxus Branchisotoma belcheri. Acta Oceanologica Sinica. 2006, 25: 99-105
  24. 周魯明,劉殿辰,孫歡歡,趙博生*. 東亞三角渦蟲胰蛋白酶Djtry的表達(dá)和酶活分析,遺傳,2012, 34(5):609-614
  25. 吳素格,楊武,周魯明,趙博生*. P53同系物Djp53在渦蟲胚基早期發(fā)育階段的組織特異性表達(dá)及其在再生中的作用,中國(guó)生物化學(xué)與分子生物學(xué)報(bào),2011,27(6):561-567
  26. 聶敏,趙博生*. 東亞三角渦蟲RhoA基因的原核表達(dá)及組織定位,中國(guó)細(xì)胞生物學(xué)學(xué)報(bào),2011, 33(7):784-788
  27. 袁佐清,趙博生*. 東亞三角渦蟲DjPreb基因干擾載體的構(gòu)建及干擾效果鑒定,生物技術(shù)通報(bào),2011, 9:120-124 (責(zé)任作者)
  28. 劉斌,趙博生*. 東亞三角渦蟲PSA蛋白的表達(dá)、鑒定及抑菌分析,生物技術(shù)通報(bào),2011,6: 134-139 (責(zé)任作者)
  29. 杜曉琪,趙博生*. 青島文昌魚S-腺苷高半胱氨酸水解酶基因的組織特異性表達(dá),四川動(dòng)物,2011,30(3):344-347 (責(zé)任作者)
  30. 王源,趙博生*. 青島文昌魚S-腺苷高半胱氨酸水解酶基因表達(dá)載體的構(gòu)建及表達(dá)純化,四川動(dòng)物,2009,28(1):11-14 (責(zé)任作者)
  31. 曲曉娟,王源,耿文君,趙博生*. 東亞三角渦蟲cDNA文庫(kù)的構(gòu)建及EST初步分析,四川動(dòng)物,2008,27(2):205-209 (責(zé)任作者)
  32. 肖勤、張士璀、趙博生*,壬基酚對(duì)成體玫瑰無(wú)須鲃性腺的毒性效應(yīng),環(huán)境科學(xué),2007,28(11):2580-2585 (責(zé)任作者)
   獲得學(xué)術(shù)獎(jiǎng)勵(lì)
  張士璀、劉振輝、李國(guó)榮、王長(zhǎng)法、趙博生,模式動(dòng)物文昌魚的個(gè)體發(fā)育和系統(tǒng)發(fā)育,山東省自然科學(xué)獎(jiǎng)一等獎(jiǎng) (2007年)?!?br />
  主持和參與的主要科研項(xiàng)目  
  1. 魚類抗感染免疫的分子與細(xì)胞基礎(chǔ)及其調(diào)控(2006CB101805)子課題,國(guó)家973,2007-2011, 主持
  2. 文昌魚假定基因的功能預(yù)測(cè)與驗(yàn)證(2008AA09Z411),國(guó)家863,2008-2010, 第三位
  3. Dj14-3-3ε基因在渦蟲神經(jīng)再生中的功能研究 (ZR2009DM029),山東省自然基金,2009-2012, 主持
  4. 文昌魚下丘腦-腺垂體-甲狀腺調(diào)控軸相關(guān)基因的克隆、表達(dá)和進(jìn)化分析 (208077),教育部重點(diǎn)研究項(xiàng)目,2008-2010, 主持
  5. 文昌魚酚氧化酶的進(jìn)化與功能研究 (30700071),國(guó)家自然基金,2008-2010,第二位
  6. 渦蟲補(bǔ)體C3的進(jìn)化和功能及其激活途徑的研究(31172074),國(guó)家自然基金,2012-2015,第二位
  7. 全氟辛烷磺酸對(duì)渦蟲神經(jīng)再生毒性及其機(jī)理研究(31100377),國(guó)家自然基金,2012-2014,第二位   

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