招生人數(shù):8

課題組長(zhǎng)簡(jiǎn)介

周磊，男，39歲，廣西大學(xué)動(dòng)物科學(xué)技術(shù)學(xué)院教授、博士生導(dǎo)師，副院長(zhǎng)。入選首批廣西壯族自治區(qū)高層次人才、廣西優(yōu)秀專家、廣西“百人計(jì)劃”，獲廣西青年五四獎(jiǎng)?wù)?，中?guó)畜牧獸醫(yī)學(xué)會(huì)動(dòng)物遺傳育種學(xué)分會(huì)理事、生理生化學(xué)分會(huì)理事，農(nóng)業(yè)生物化學(xué)與分子生物學(xué)分會(huì)理事，亞熱帶農(nóng)業(yè)生物資源保護(hù)與利用國(guó)家重點(diǎn)實(shí)驗(yàn)室固定研究人員。先后留學(xué)德國(guó)糖尿病研究中心（杜塞爾多夫）、法國(guó)原子能委員會(huì)（巴黎）、美國(guó)賓夕法尼亞大學(xué)（費(fèi)城）。2013年作為學(xué)術(shù)帶頭人引進(jìn)到廣西大學(xué)，建立分子營(yíng)養(yǎng)課題組。廣西大學(xué)是雙一流學(xué)科建設(shè)高校，入選教育部部區(qū)合建高校。課題組隸屬國(guó)家重點(diǎn)實(shí)驗(yàn)室和自治區(qū)一流建設(shè)學(xué)科，課題組現(xiàn)有動(dòng)物代謝籠、核磁、CT等大型設(shè)備，具有生物化學(xué)和分子生物學(xué)研究的常規(guī)設(shè)備，在今后幾年的雙一流建設(shè)中還將購(gòu)置近千萬(wàn)的設(shè)備，實(shí)驗(yàn)平臺(tái)不弱于國(guó)內(nèi)、抑或國(guó)外相關(guān)專業(yè)。課題組正在開展基因功能、高通量測(cè)序分析、小分子化合物篩選和設(shè)計(jì)（已購(gòu)置Discovery Studio軟件）等工作，目前已積累非常豐富的組學(xué)數(shù)據(jù)，非常歡迎對(duì)生物、生物信息、分子模擬、化學(xué)生物學(xué)感興趣的同學(xué)加入。聯(lián)系方式：zhoulei@gxu.edu.cn。

研究方向

營(yíng)養(yǎng)組學(xué)研究（功能基因組、表觀基因組、蛋白質(zhì)組、蛋白質(zhì)修飾組）

營(yíng)養(yǎng)小分子的篩選、設(shè)計(jì)和功能研究

動(dòng)物重要經(jīng)濟(jì)性狀的遺傳改良

動(dòng)物生理代謝調(diào)控

功能基因的轉(zhuǎn)錄調(diào)控和信號(hào)轉(zhuǎn)導(dǎo)

社會(huì)兼職

中國(guó)畜牧獸醫(yī)學(xué)會(huì)動(dòng)物遺傳育種學(xué)分會(huì)理事

中國(guó)畜牧獸醫(yī)學(xué)會(huì)動(dòng)物生理生化學(xué)分會(huì)理事

農(nóng)業(yè)生物化學(xué)與分子生物學(xué)分會(huì)理事

廣西實(shí)驗(yàn)動(dòng)物學(xué)會(huì)常務(wù)理事

碩士生要求

1. 生物、基礎(chǔ)醫(yī)學(xué)、計(jì)算化學(xué)等相關(guān)專業(yè)

2. 對(duì)生命科學(xué)研究、對(duì)大數(shù)據(jù)分析有濃厚興趣

3. 做事認(rèn)真踏實(shí)，責(zé)任心強(qiáng)，有良好的與人相處和溝通的能力及團(tuán)隊(duì)合作精神

4. 具備良好的英語(yǔ)讀寫能力

相關(guān)待遇

碩士生除享有國(guó)家和課題組固定津貼，根據(jù)科研績(jī)效還享有課題組額外獎(jiǎng)勵(lì)，優(yōu)秀的同學(xué)可申請(qǐng)碩博連讀。

課題組情況

分子營(yíng)養(yǎng)課題組依托廣西大學(xué)動(dòng)物科學(xué)技術(shù)學(xué)院和亞熱帶農(nóng)業(yè)生物資源保護(hù)與利用國(guó)家重點(diǎn)實(shí)驗(yàn)室，研究方向?yàn)樘侵x調(diào)控，在醫(yī)學(xué)上主要針對(duì)肥胖、糖尿病、脂肪肝等代謝疾??；在畜牧上研究脂肪性狀對(duì)繁殖、肉質(zhì)、瘦肉率的調(diào)控。已在hepatology、nucleic acids research等高水平雜志上發(fā)表多篇論文。課題組長(zhǎng)周老師入選廣西自治區(qū)優(yōu)秀專家、百人計(jì)劃、廣西大學(xué)杰出人才培養(yǎng)計(jì)劃，團(tuán)隊(duì)承擔(dān)多項(xiàng)國(guó)家級(jí)、省部級(jí)研究課題。

1. 周老師從科研思路、實(shí)驗(yàn)技能和論文寫作方面親自指導(dǎo)學(xué)生，與學(xué)生一起做研究，全方位培養(yǎng)學(xué)生

2. 課題組與美國(guó)、德國(guó)等多個(gè)課題組保持著長(zhǎng)期合作關(guān)系，優(yōu)秀研究生和博士后根據(jù)項(xiàng)目進(jìn)展和合作需要，有機(jī)會(huì)赴德國(guó)或美國(guó)進(jìn)行聯(lián)合培養(yǎng)或合作研究，畢業(yè)或出站后盡力推薦去國(guó)外一流課題組繼續(xù)深造

3. 博士后和研究生每年至少參加一次國(guó)內(nèi)學(xué)術(shù)會(huì)議

4. 課題組工作氛圍輕松友善，為團(tuán)隊(duì)成員提供實(shí)現(xiàn)自身價(jià)值的機(jī)會(huì)及發(fā)展空間

5. 先進(jìn)的課題組運(yùn)行模式，每個(gè)成員都有獨(dú)立項(xiàng)目

6. 較為充足的研究經(jīng)費(fèi)（詳見主持項(xiàng)目）

7. 充足的實(shí)驗(yàn)空間和優(yōu)良的實(shí)驗(yàn)設(shè)備，具有課題組專用的細(xì)胞培養(yǎng)室和動(dòng)物房

主持項(xiàng)目

1. 廣西科技基地和人才專項(xiàng)，2018/12-2021/11。

2. 國(guó)家重點(diǎn)研發(fā)計(jì)劃，2018/06-2020/12。

3. 廣西大學(xué)高層次專業(yè)技術(shù)人才培養(yǎng)工程“杰出人才培養(yǎng)計(jì)劃”，2015/08-2021/07。

4. 國(guó)家自然科學(xué)基金，2014/01-2016/12；2017/01-2020/12。

5. 廣西高校引進(jìn)海外高層次人才“百人計(jì)劃”，2014年。

6. 廣西自然科學(xué)基金重點(diǎn)項(xiàng)目，2014/06-2017/05；2020/01-2023/12。

7. 廣西大學(xué)科研基金（引進(jìn)人才項(xiàng)目），2013/07-2018/06。

8. 歐洲糖尿病研究基金項(xiàng)目（efsd，歐洲基金會(huì)資助），2012/01-2013/06。

9. 教育部博士點(diǎn)新教師基金，2011/01-2013/12。

10. tanita健康體重基金（日本基金會(huì)資助），2009/10-2010/10。

11. 歐洲糖尿病研究基金項(xiàng)目（efsd，歐洲基金會(huì)資助），2006/10-2007/03。

近年代表作

第一/通訊作者（*）

1. Lei Zhou*, Xiaolan Yu, Qingjie Meng, Hongqiang Li, Congcong Niu, Yun Jiang, Yuxi Cai, Minghui Li, Qiang Li, Chaoqiang An, Le Shu, Ao Chen, Handong Su, Yin Tang, Shen Yin, Silja Raschke, Kristin Eckardt, Juergen Eckel, Zaiqing Yang*. Resistin reduces mitochondria and induces hepatic steatosis in mice by the protein kinase C/protein kinase G/p65/PPAR gamma coactivator 1 alpha pathway. Hepatology. 2013, 57: 1384-1393. IF：14.971

2. Lei Zhou, Gwenaelle Le Roux, Cecile Ducrot, Stephane Chedin, Jean Labarre, Michel Riva, Christophe Carles*. Repression of class I transcription by cadmium is mediated by the Protein Phosphatase 2A. Nucleic Acids Res. 2013, 41: 6087–6097. IF：11.147

3. Yixing Li, Kejing Wu, Weili Quan, Lin Yu, Shuang Chen, Chao Cheng, Qijia Wu, Shuhong Zhao, Yi Zhang*, Lei Zhou*. The dynamics of FTO binding and demethylation from the m6A motifs. RNA Biology. 2019, 16: 1179–1189. IF：5.477

4. Zupeng Luo, Zhiwang Zhang, Lina Tai, Lifang Zhang, Zheng Sun, Lei Zhou*. Comprehensive analysis of differences of N6-methyladenosine RNA methylomes between high-fat-fed and normal mouse livers. Epigenomics. 2019, 11(11): 1267-1282. IF: 4.404

5. Zhanyang Tang, Yi Zhou, Jun Xiao, Huan Zhong, Weiwei Miao, Zhongbao Guo, Xu Zhang, Lei Zhou*, Yongju Luo*. Transcriptome Analysis of Ovary Development in Nile Tilapia Under Different Photoperiod Regimes. Frontiers in Genetics. 2019, 10: 894. IF: 3.517

6. Lifang Zhang, Yilin Qi, Zhier ALuo, Siqi Liu, Zhiwang Zhang and Lei Zhou*. Betaine increases mitochondrial content and improves hepatic lipid metabolism. Food & Function. 2019, 10: 216-223. IF：3.241

7. Qiang Li, Yixing Li, Zhiwang Zhang, Huifang Kang, Lifang Zhang, Yuxiang Zhang, Lei Zhou*. SEIPIN overexpression in the liver may alleviate hepatic steatosis by influencing the intracellular calcium level. Mol Cell Endocrinol. 2019, 488: 70-78. IF：3.693

8. Li Y, Luo Z, Wu X, Zhu J, Yu K, Jin Y, Zhang Z, Zhao S, Zhou L*. Proteomic Analyses of Cysteine Redox in High-Fat-Fed and Fasted Mouse Livers: Implications for Liver Metabolic Homeostasis. J Proteome Res. 2018, 17(1): 129-140. IF：3.78

9. Kang Huifang, Zhang Zhiwang, Yu Lin, Li Yixing*, Liang Mingzhen, Zhou Lei*. FTO reduces mitochondria and promotes hepatic fat accumulationthrough RNA demethylation. Journal of Cellular Biochemistry. 2018, 119(7): 5676-5685. IF：3.448

10. Yixing Li, Huifang Kang, Yi Chu, Yi Jin, Lifang Zhang, Ranran Yang, Zhiwang Zhang, Shuhong Zhao, Lei Zhou*. Cidec differentially regulates lipid deposition and secretion through two tissue-specific isoforms. Gene. 2018, 641C: 265-271. IF：2.415

11. Lin Yu, Lina Tai, Lifang Zhang, Yi Chu, Yixing Li*, Lei Zhou*. Comparative analyses of long non-coding RNA in lean and obese pig. Oncotarget. 2017, 8(25): 41440-41450. IF：5.168

12. Yuxiang Zhang, Yixing Li, Lin Yu, Lei Zhou*. Association between serum resistin concentration and hypertension: A systematic review and meta-analysis. Oncotarget. 2017, 8(25): 41529-41537. IF：5.168

13. Yixing Li, Yi Chu, Lin Yu, Huifang Kang, Lei Zhou*. Transcriptomic analysis of Bama pig's liver in various nutritional status reveals a metabolic difference of fatty acid. Food & Function. 2017, 8: 3480-3490. Cover Paper, IF：3.241

14. Qiang Li, Yuxi Cai, Jing Huang, Xiaolan Yu, Jun Sun, Zaiqing Yang*, Zhou L*. Resistin impairs glucose permeability in EA.hy926 cells by downregulating GLUT1 expression. Mol Cell Endocrinol. 2016, 434: 127-34. IF：3.693

15. Jiang Y, Lu L, Hu Y, Li Q, An C, Yu X, Shu L, Chen A, Niu C, Zhou L*, Yang Z*. Resistin Induces Hypertension and Insulin Resistance in Mice via a TLR4-Dependent Pathway. Sci Rep. 2016, 6: 22193. IF：4.259

16. Y Li, L Zhou*, Vitamin D Deficiency, Obesity and Diabetes. Cell Mol Biol. 2015, 61(3): 35-38. IF：0.92

17. Li H, Chen A, Shu L, Yu X, Gan L, Zhou L*, Yang Z*. Translocation of CIDEC in hepatocytes depends on fatty acids. Genes Cells. 2014, 19(11): 793-802. IF：1.993

18. Lei Zhou, Lijie Zhang, Qingjie Meng, Congcong Niu, Dan Jin, An Yu, Li gan, Zaiqing Yang. C/EBP? promotes transcription of the porcine perilipin5 gene. Mol Cell Endocrinnol. 2012, 364:28-35. IF：3.693

19. Lei Zhou, Qingjie Meng, Tao Qian, Zaiqing Yang. Ginkgo biloba extract enhances glucose tolerance in hyperinsulinism-induced hepatic cells. J Nat Med. 2011, 65(1): 50-6. IF：1.982

20. Lei Zhou, Henrike Sell, Kristin Eckardt, Zaiqing Yang, Jürgen Eckel. Conditioned medium obtained from in vitro differentiated adipocytes and resistin induce insulin resistance in human hepatocytes. FEBS letters. 2007, 581: 4303-4308. IF：3.623

21. Lei Zhou, Yixing Li, Tao Nie, Shengqiu Feng, Huaping Chen, Zaiqing Yang. Clenbuterol inhibits SREBP-1c expression by activating CREB1. J BIOCHEM MOL BIOL. 2007, 40(4): 525-31. IF：2.021

22. Lei Zhou, Yixing Li, Tao Xia, Shengqiu Feng, Xiaodong Chen, Zaiqing Yang. Resistin Overexpression Impaired Glucose Tolerance in Hepatocytes. Eur Cytokine Netw. 2006, 17(3): 189-95. IF：2.364

23. Lei Zhou, Tao Xia, Yixing Li, Xiaodong Chen, Yin Peng, Zaiqing Yang. Transcriptional Regulation of the Resistin Gene. Domest Anim Endocrinol. 2006, 30(2): 98-107. IF：1.644

合作論文

24. Chen Ao, Chen Xiaodong, Cheng Shiqiang, Shu Le, Yan Meiping, Yao Lun, Wang Binyu, Huang Shuguang, Zhou Lei, Yang Zaiqing, Liu Guoquan. FTO promotes SREBP1c maturation and enhances CIDEC transcription during lipid accumulation in HepG2 cells. Biochimica et Biophysica Acta – Molecular and Cell Biology of Lipids. 2018, 1863(5): 538-548. IF：5.547

25. Yanling Wu, Qinqiang Long, Bin Feng, Xiaoyue Zhu, Zifeng Zheng, Sumin Gao, Mingju Gao, Li Gan, Lei Zhou, Zaiqing Yang. Molecular cloning and characterization of the anti-obesity gene adipose in pig. Gene. 2012, 509: 110-9. IF：2.415

26. Chen Z, Gao X, Lei T, Chen X, Zhou L, Yu A, Lei P, Zhang R, Long H, Yang Z. Molecular characterization, expression and chromosome localization of porcine PNPLA3 and PNPLA4. Biotechnol Lett. 2011, 33(7): 1327-37. IF：1.73

27. Zhang J, Lei T, Chen X, Peng Y, Long H, Zhou L, Huang J, Chen Z, Long Q, Yang Z. Resistin Up-Regulates COX-2 Expression via TAK1-IKK-NF-kappaB Signaling Pathway. Inflammation. 2010, 33(1): 25-33. IF：2.955

28. Qi YM, Lei T, Zhou L, Chen XD, Long QQ, Long H, Jin D, Gan L, Yang ZQ. Genomic organization, alternative splicing and tissues expression of porcine CREB3L4 gene. Mol Biol Rep. 2009, 36(7): 1881-8. IF：1.828

29. Y. H. Li, T. Lei, X. D. Chen, T. Xia, Q. Q. Long, J. Zhang, S. Q. Feng, Y. Peng, L. Zhou, Z. Q. Yang. Molecular cloning, chromosomeal location and expression pattern of porcine CIDEa and CIDEc. Mol Biol Rep. 2009, 36(3): 575-82. IF：1.828

30. Qi M, Lei T, Zhou L, Chen XD, Long H, Long QQ, Zhang RR, Yang ZQ, Gan L. Cloning, Characterization, Chromosomal Mapping and Tissue Transcription Analysis of Porcine CREB2 and CREB3 Genes. Folia Biol. 2009, 55(4): 137-44. IF：0.939

31. Huaping Chen, Wenshu Yao, Dan Jin, Tao Xia, Xiaodong Chen, Ting Lei, Lei Zhou, Zaiqing Yang. Cloning, Expression Pattern, Chromosomal Localization, and Evolution Analysis of Porcine Gnaq, Gna11, and Gna14. Biochem Genet. 2008, 46(7-8): 398-405. IF：1.543

32. Y Li, L Zhou, Y Li, D Chen, X Tan, L Lei and J Zhou. A Nodule-Specific Plant Cysteine Proteinase, AsNODF32, Is Involved in Nodule Senescence and Nitrogen Fixation Activity of the Green Manure Legume Astragalus sinicus. New Phytologist. 2008, 180: 185-192. IF：7.33

33. Huaping Chen, Tao Xia, Lei Zhou, Xiaodong Chen, Li Gan, Wenshu Yao, Yin Peng, and Zaiqing Yang. Gene organization, alternate splicing and expression pattern of porcine visfatin gene. Domest Anim Endocrinol. 2007; 32: 235-45. IF：1.644

34. HW Yang, T Xia, ZL Chen, SQ Feng, Y Peng, L Zhou, L Gan, and ZQ Yang. Cloning, chromosomal localization and expression patterns of porcine Kruppel-like factors 4, -5, -7 and the early growth response factor 2. Biotechnol Lett. 2007; 29(1): 157-63. IF：1.73

35. Feng SQ, Chen XD, Xia T, Gan L, Qiu H, Dai MH, Zhou L, Peng Y, Yang ZQ. Cloning, chromosome mapping and expression characteristics of porcine ANGPTL3 and -4. Cytogenet Genome Res. 2006; 114(1): 44-9. IF：1.354

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