廣州醫(yī)科大學(xué)導(dǎo)師:賀智敏

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廣州醫(yī)科大學(xué)導(dǎo)師:賀智敏

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廣州醫(yī)科大學(xué)導(dǎo)師:賀智敏 正文

[導(dǎo)師姓名]
賀智敏

[所屬院校]
廣州醫(yī)科大學(xué)

[基本信息]
導(dǎo)師姓名:賀智敏
性別:男
人氣指數(shù):781
所屬院校:廣州醫(yī)科大學(xué)
所屬院系:
職稱:教授
導(dǎo)師類型:博導(dǎo)
招生專業(yè):腫瘤學(xué)
研究領(lǐng)域:惡性腫瘤發(fā)病和治療耐受的分子機(jī)制



[通訊方式]
辦公電話:020-83492353
電子郵件:hezhimin2005@yahoo.com

[個人簡述]
賀智敏,男,醫(yī)學(xué)博士,廣州醫(yī)學(xué)院教授,博士生導(dǎo)師;現(xiàn)任廣州醫(yī)學(xué)院腫瘤研究所所長兼附屬腫瘤醫(yī)院中心實(shí)驗(yàn)室主任。1982年畢業(yè)于湖南醫(yī)學(xué)院醫(yī)療系,先后獲學(xué)士、碩士、博士學(xué)位;1998年2007年間作為訪問學(xué)者先后在香港大學(xué)微生物系、美國杜克大學(xué)癌癥研究中心及美國科羅拉多大學(xué)醫(yī)學(xué)中心工作4年。現(xiàn)擔(dān)任湖南省病理生理學(xué)會副理事長兼秘書長,國際病理科學(xué)與臨床雜志副主編及多家雜志編委;廣州市“腫瘤學(xué)”重點(diǎn)扶持學(xué)科項(xiàng)目負(fù)責(zé)人。先后主持國家自然基金3項(xiàng)、省部級科研課題4項(xiàng),其他項(xiàng)目5余項(xiàng),在Nature?Medicine,Cell?stem?Cell,Cancer?Res,?Nucleic?Acids?Research,?Oncogene,?Cancer?Letter等雜志發(fā)表科研論文110余篇,其中SCI收錄論文40篇。獲得2項(xiàng)省級成果,培養(yǎng)博士研究生8名,碩士研究生30名,在站博士后1人。

[科研工作]
近3年以通訊作者發(fā)表的主要文章:1.??Weijia?Zhang,Meilin?Feng,Guopei?Zheng,Ye?Chen,Xuedong?Wang,Bo?Peng,Jiang?Yin,?Yanhui?Yu,?Zhimin?He?Chemoresistance?to?5-?uorouracil?induces?epithelial-?mesenchymal?transition?via?up-regulation?of?Snail?in?MCF7?human?breast?cancer?cells.?Biochem.?Biophys.?Res.?Commun.?2012,417:679-685?(IF-2.595)?2.??Guopei?Zheng,?Yan?Xiong,,?Sisi?Yi,,?Weijia?Zhang,?Bo?Peng,?Qiong?Zhang,?Zhimin?He14-3-3r?regulation?by?p53?mediates?a?chemotherapy?response?to?5-?uorouracil?in?MCF-7?breast?cancer?cells?via?Akt?inactivation??FEBS?Lett.?2012,?586:163-168??(IF-3.601)3.??Bo?Peng,?Sisi?Yi,?Yixue?Gu,?Guopei?Zheng?and?Zhimin?He?Purification?and?biochemical?characterization?of?a?novel?protein―tongue?cancer?chemotherapy?resistance-associated?protein1?(TCRP1)?Protein?Expression?and?Purification.?2012,82:360-367?(IF-1.644)4.??Weijia?Zhang,?Wei?Ding,?Ye?Chen,?Meilin?Feng,?Yongmei?Ouyang,?Yanhui?Yu,?Zhimin?He.?Upregulation?of?breast?cancer?resistance?protein?plays?a?role?in?HER2-mediated?chemoresistance?through?PI3K/Akt?and?nuclear?factor-kappa?B?signaling?pathways?in?MCF-7?breast?cancer?cells.?Acta?Biochim?Biophys.?Sin.?2011,43:647-53?(IF=1.547)5.??Yixue?Gu,?Shasha?Fan,?Yan?Xiong,?Bo?Peng,?Guopei?Zheng,?Yanhui?Yu,?Yongmei?Ouyang,Zhimin?He?Cloning?and?functional?characterization?of?TCRP1,?a?novel?gene?mediating?resistance?to?cisplatin?in?an?oral?squamous?cell?carcinoma?cell?line?.?FEBS?letters.?2011,585:881-887??(IF-3.601)6.??Gu?Y,?Fan?S,?Liu?B,?Zheng?G,?Yu?Y,?Ouyang?Y,?He?Z.?TCRP1?promotes?radioresistance?of?oral?squamous?cell?carcinoma?cells?via?Akt?signal?pathway.?Mol?Cell?Biochem.?2011,357:107-113??(IF=2.168)7.??Xuedong?Wang,?Xingang?Wu,?Chengkun?Wang,?Weijia?Zhang,?Yanhui?Yu,?Yongmei?ouyang,?Zhimin?He?Transcriptional?suppression?of?breast?cancer?resistance?protein?(BCRP)?by?wild-type?p53?through?NF-κB?pathway?in?MCF-7?cells?FEBS?letters.?2010,584:3392-3397?(IF-3.601)8.?Guopei?Zheng,?Fang?Peng,?Renkui?Ding,?Yanhui?Yu,Yongmei?Ouyang,?Zhuchu?Chen,?Zhiqiang?Xiao,?Zhimin?He.?Identification?of?proteins?responsible?for?the?multiple?drug?resistance?in?5-Fluorouracil-induced?breast?cancer?cell?using?proteomics?analysis?J.?Cancer?Res?and?Clinical?Oncology?2010,?136(10):1477-88?(IF=2.485)9.?Guopei?Zheng,?Min?Zhou,?Xinrong?Ou,?Bo?Peng,?Yanhui?Yu,?Fangren?Kong,?Yongmei?Ouyang,?Zhimin?He.?Identification?of?CA?Ⅸ?as?a?contributor?to?pingyangmycin?induced?drug?resistance?in?human?tongue?cancer?cell.?FEBS?Journal.?2010,277:4506-4518??(JF=3.129)10.?Cheng-kun?Wang,?Jian-guo?Cao,?Bo?Peng,?Yi-xue?Gu,?Guo-pei?Zheng,?Zhi-min?He.?Inhibition?of?growth?and?motility?of?human?A549?lung?carcinoma?cells?by?a?recombined?vascular?basement?membrane?derived?peptide.?Cancer?Letter??2010,?292:?261-268(IF=4.864)11.?Cheng-kun?Wang,?Jian-guo?Cao,?Jia-quan?Qu,?Bo?Peng,?Yi-xue?Gu,?Zhi-min?He.?Recombinant?vascular?basement?membrane?derived?multifunctional???peptide?blocks?endothelial?cell?angiogenesis?&?Neovascularization?J.?Cell?Biochemisthy?2010,?111(2):453-60.(IF=3.422)12.?X.?D.Wang,?B.?L.?Wang,?S.?L.?Ye,?Y.?Q.?Liao,?L.?F.?Wang?and?Z.?M.?He.??Non-invasive?foetal?RHD?genotyping?via?real-time?PCR?of?foetal?DNA?from?Chinese?RhD-negative?maternal?plasma.?Eur?J?Clin?Invest??2009?39?(7):?607?617?(IF?2.8?)13.?Janhui?Yuan,?Hui?Lv,?Bo?Peng,?Chengkun?Wang,?Yanhui?Yu,?Zhimin?He.?Role?of?BCRP?as?a?biomarker?for?predicting?resistance?to?5-fluorouracil?in?breast?cancer.?Cancer?Chemother?Pharmacol.?2009,63:1103-1110?(IF=2.74)

[教育背景]
廣州醫(yī)科大學(xué)

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