大連醫(yī)科大學(xué)基礎(chǔ)醫(yī)學(xué)院導(dǎo)師：辛毅 正文

[導(dǎo)師姓名]
辛毅

[所屬院校]
大連醫(yī)科大學(xué)

[基本信息]
導(dǎo)師姓名：辛毅
性別：
人氣指數(shù)：1033
所屬院校：大連醫(yī)科大學(xué)
所屬院系：基礎(chǔ)醫(yī)學(xué)院
職稱：教授
導(dǎo)師類型：博導(dǎo)
招生專業(yè)：

[通訊方式]
辦公電話：0411-86110295
電子郵件：jimxin@hotmail.com

[個(gè)人簡(jiǎn)述]
辛毅，博士，教授，博士生導(dǎo)師。1996年4月在美國(guó)科羅拉多州立大學(xué)微生物系完成博士后研究后回國(guó)，在大連醫(yī)科大學(xué)任教至今。2003年入選 “遼寧省新世紀(jì)百千萬(wàn)人才工程”的百層次人選，獲第三屆大連市歸國(guó)留學(xué)人員創(chuàng)業(yè)英才標(biāo)兵、大連醫(yī)科大學(xué)名師等榮譽(yù)。任大連市醫(yī)學(xué)會(huì)生化?？品謺?huì)委員、遼寧省生物化學(xué)與分子生物學(xué)學(xué)會(huì)常務(wù)理事、中國(guó)生物工程學(xué)會(huì)糖生物工程專業(yè)委員會(huì)委員。主持4項(xiàng)國(guó)家自然科學(xué)基金、參與國(guó)家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃、“艾滋病和病毒性肝炎等重大傳染病防治”科技重大專項(xiàng)。主要從事人體微生物組與疾病的相關(guān)性及其機(jī)制的研究。講授課程：生物醫(yī)學(xué)工程導(dǎo)論（本科）生物技術(shù)自主實(shí)驗(yàn)（本科）高級(jí)生物化學(xué)（研究生）

[科研工作]
主要學(xué)術(shù)任職 ：大連市醫(yī)學(xué)會(huì)生化?？品謺?huì)委員； 中國(guó)生物工程學(xué)會(huì)糖生物工程專業(yè)委員會(huì)委員
承擔(dān)的國(guó)家級(jí)項(xiàng)目：（近5年）1、青島瑞思德生物科技有限公司：滸苔及其多糖對(duì)腸道菌群的調(diào)節(jié)功能的確定. (2017.1. - 2019.12.，50.00 萬(wàn))，排名1
2、國(guó)家自然科學(xué)基金：結(jié)核分枝桿菌GlmU乙酰基轉(zhuǎn)移酶抑制劑的作用機(jī)制研究及抑菌效果評(píng)價(jià) (2016.01. - 2019.12.，54.00 萬(wàn))，排名2
3、高等學(xué)校博士學(xué)科點(diǎn)專項(xiàng)科研基金項(xiàng)目：分枝桿菌細(xì)胞壁LAM脂多糖結(jié)構(gòu)變化對(duì)抗原遞呈作用的調(diào)節(jié)及機(jī)制研究 (2013.01 - 2015.12.，12萬(wàn))，排名1
4、國(guó)家自然科學(xué)基金：結(jié)核分枝桿菌絲氨酸乙?；D(zhuǎn)移酶 (SAT) 的結(jié)構(gòu)與功能研究 (2011.1.- 2013.12.，32萬(wàn))，排名1
5、國(guó)家自然科學(xué)基金：恥垢分枝桿菌MSMEG_6402基因的敲除及功能研究(2010.1.- 2012.12.，32萬(wàn))，排名1
代表性論文（近5年）：例：作者、文章題目、雜志名稱（影響因子）、卷期、頁(yè)碼1.Eugene Dogkotenge Kuugbee, Shang Xueqi, Yaser Gamallat, Djibril Bamba, Annoor Awadasseid, Mohammed Ahmed Suliman, Shizhu Zang, Yufang Ma, Gift Chiwala, Yi Xin*, Dong Shang*. Structural change in microbiota by a probiotic cocktail enhances the gut barrier and reduces cancer via TLR2 signaling in a rat model of colon cancer. Digestive Diseases and Sciences (2.516), 2016, 61(10): 2908-2920.
2.Yaser Gamallat, Abdo Meyiah, Eugene D. Kuugbee, Ahmed Musa Hago, Gift Chiwala, Annoor Awadasseid, Djibril Bamba, Xin Zhang, Xueqi Shang, Fuwen Luo*, Yi Xin*. Lactobacillus rhamnosus induced epithelial cell apoptosis, ameliorates inflammation and prevents colon cancer development in an animal model. Biomedicine & Pharmacotherapy (2.326), 2016, 83:536-541.
3.Qiulong Yan, Song Cui, Changming Chen, Shenghui Li, Shanshan Sha, Xianyao Wan, Yi Xin*, Yufang Ma*. Metagenomic analysis of sputum microbiome as a tool towards culture-independent pathogen detection of patients with ventilator-associated pneumonia. American Journal of Respiratory and Critical Care Medicine (13.118), 2016, 195(5): 636-639.
4.Jianjun Liu, Qiulong Yan, Fuwen Luo, Dong Shang, Dachang Wu, Haiquan Zhang, Xueqi Shang, Xiaoli Kang, Meyiah Abdo, Beibei Liu, Yufang Ma* and Yi Xin*. Acute cholecystitis associated with infection of Enterobacteriaceae from gut microbiota. Clinical Microbiology and Infection (4.575), 2015, 21(9):851.e1-9.
5.Affhan Shoaib, Dachang Wu, Yi Xin*. Determining the role of a probiotic in the restoration of intestinal microbial balance by molecular and cultural techniques. Genetics and Molecular Research (0.764), 2015, 14(1):1526-1537.6.Lawrence Owusu, Bo Wang, Yue Du, Weiling Li and Yi Xin*. The quantum of initial transformed cells potentially modulates the type of local inflammation mechanism elicited by surrounding normal epithelial tissues and systemic immune pattern for tumor arrest or progression. Journal of Cancer (3.609), 2015, 6(2): 128-138.
7.Yunjuan Zhang, Wei Duan, Lawrence Owusu, Dachang Wu, Yi Xin*. Epigallocatechin 3 gallate induces the apoptosis of hepatocellular carcinoma LM6 cells but not non cancerous liver cells. International Journal of Molecular Medicine (2.348), 2015, 35(1): 117-124.
8.Tao Jiang, Lina Cai, Xiaojiao Zhao, Lianqi He, Yufang Ma, Shizhu Zang, Cuili Zhang, Xinli Li, Yi Xin*. Functional identification of MSMEG_6402 protein from Mycobacterium smegmatis in decaprenylphosphoryl-D-arabinose biosynthesis. Microbial Pathogenesis (2014), 76: 44-50. (IF2013: 2.0 IF2014: 1.794)
9.Dachang Wu, Chenxia Hou, Yanxia Li, Zinan Zhao, Jianjun Liu, Xin Lu, Xueqi Shang, Yi Xin*. Analysis of the bacterial community in chronic obstructive pulmonary disease sputum samples by denaturing gradient gel electrophoresis and real-time PCR. BMC Pulmonary Medicine (2.404), 2014, 14:179.
10.Lei Zhou, Xinli Li, Ayaz Ahmed, Dachang Wu, Liang Liu, Juanjuan Qiu, Yao Yan, Meilan Jin, Yi Xin*. Gut microbe analysis between hyperthyroid and healthy individuals. Current Microbiology (1.423), 2014, 69(5): 675-680.
11.Weiling Li, Yi Xin, Chen Yang, Li Xinli, Cuili Zhang, Jing Bai and Jieli Yuan. The anti-proliferative effects and mechanisms of low molecular weight scorpion BmK venom peptides on human hepatoma and cervical carcinoma cells in vitro. Oncology Letter (1.554), 2014, 8(4): 1581-1584.
12.Juanjuan Qiu, Yufang Ma, Lawrence Owusu, Tao Jiang, Yi Xin*. Functional analysis of serine acetyltransferase from Mycobacterium smegmatis. Journal of Basic Microbiology (1.823), 2014, 54:1-8.
13.Ying Wan, Yi Xin, Cuili Zhang, Dachang Wu, Dapeng Ding, Li Tang, Lawrence Owusu, Jing Bai, Weiling Li. Fermentation supernatants of Lactobacillus delbrueckii inhibit growth of human colon cancer cells and induce apoptosis through a caspase 3-dependent pathway. Oncology Letters (1.554), 2014, 7: 1738-1742.
14.Xinli Li, Guang Yang, Cuili Zhang, Dachang Wu, Li Tang, Yi Xin*. Improvement of intestinal microflora balance by polysaccharide from Physalis alkekengi var. francheti. Molecular Medicine Reports (1.554), 2014, 9:677-682.
15.Yunjuan Zhang, Lawrence Owusu, Wei Duan, Tao Jiang, Shizhu Zang, Ayaz Ahmed, Yi Xin*. Anti-metastatic and differential effects on protein expression of epigallocatechin-3-gallate in HCCLM6 hepatocellular carcinoma cells. International Journal of Molecular Medicine (1.88), 2013, 32:959-964.
16.Juanjuan Qiu, Daiqing Wang, Yufang Ma, Tao Jiang, Yi Xin*. Identification and characterization of serine acetyltransferase encoded by the Mycobacterium tuberculosis Rv2335 gene. International Journal of Molecular Medicine (1.88), 2013, 31(5):1229-1233.
17.Xinli Li, Cuili Zhang, Weiling Li, Dachang Wu, Jianjun Liu, Li Tang, Yi Xin*. In vivo effects on the intestinal microflora of Physalis alkekengi var. francheti extracts. Fitoterapia (2.216), 2013, 87:43-48.
18.Xinli Li, Cuili Zhang, Dachang Wu, Li Tang, Xuejiao Cao, Yi Xin*. In vitro effects on intestinal bacterium of physalins from Physalis alkekengi var. Francheti. Fitoterapia, 2012, 83(8):1460-1465.

[教育背景]
1988年09月 - 1994年05月，理學(xué)博士 美國(guó) North Dakota State University；
1986年08月 - 1988年08月，理學(xué)碩士 美國(guó) Marshall University；
1980年09月 - 1984年07月，理學(xué)學(xué)士 河南師范大學(xué)。

大連醫(yī)科大學(xué)

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