姚文兵 ，教授，男，博士生導(dǎo)師，中國藥科大學(xué)副校長

主要經(jīng)歷
1962年6月生，1983年畢業(yè)于中國藥科大學(xué)生物制藥專業(yè)，后獲碩士、博士學(xué)位。1990年研究生畢業(yè)后留校任教。
自留校任教以來，一直從事教學(xué)、科研和管理工作?，F(xiàn)任中國藥科大學(xué)微生物與生化藥學(xué)教授（博士生導(dǎo)師）、中國藥科大學(xué)副校長。兼任國家食品藥品監(jiān)督管理局藥品、保健食品評審委員，國家發(fā)改委藥品價(jià)格決策專家委員會委員，中國生物化學(xué)與分子生物學(xué)會工業(yè)化專業(yè)委員會委員，教育部高職高專藥品類專業(yè)教學(xué)指導(dǎo)委員會主任委員，教育部高等學(xué)校藥學(xué)專業(yè)教學(xué)指導(dǎo)分委員會秘書長，全國高等醫(yī)學(xué)教育學(xué)會副秘書長，全國高等醫(yī)學(xué)教育學(xué)會藥學(xué)教育研究會副理事長兼秘書長，《藥物生物技術(shù)》副主編，《藥學(xué)教育》常務(wù)副主編，《中國藥學(xué)年鑒》、《中國藥科大學(xué)學(xué)報(bào)》等雜志編委。

主要科研工作簡介
主要從事的研究領(lǐng)域
多肽、蛋白質(zhì)類藥物的分子改構(gòu)（包括基于基因密碼子擴(kuò)展的分子改構(gòu)）和定點(diǎn)修飾研究以及生物新藥的研制。

課題資助情況
在以上研究領(lǐng)域已主持完成了國家科技重大專項(xiàng)課題、國家863項(xiàng)目、國家自然科學(xué)基金項(xiàng)目、教育部重點(diǎn)項(xiàng)目、江蘇省重點(diǎn)項(xiàng)目等國家及省部級課題26項(xiàng)。目前正主持國家自然科學(xué)基金、國家科技重大專項(xiàng)課題、博士點(diǎn)基金、江蘇省科技創(chuàng)新與成果轉(zhuǎn)化專項(xiàng)等項(xiàng)目7項(xiàng)。

完成的主要科研工作及獲獎情況
長期從事多肽、蛋白質(zhì)類藥物的分子改構(gòu)（包括基于基因密碼子擴(kuò)展的分子改構(gòu)）和定點(diǎn)修飾研究以及生物新藥的研制，圍繞多肽和蛋白質(zhì)藥物的分子改構(gòu)及其在創(chuàng)新藥物中應(yīng)用開展系列研究，1）建立了與國際前沿同步的非天然氨基酸定點(diǎn)改構(gòu)技術(shù)體系；2）建立了多肽、蛋白質(zhì)類藥物修飾技術(shù)平臺和質(zhì)量評價(jià)體系，3）開展長效多肽、蛋白質(zhì)類創(chuàng)新藥物研究，完成了PEG—ED、PEG2—IFNcon 等長效蛋白質(zhì)類藥物和長效多肽類藥物的臨床前研究。在該領(lǐng)域主持國家“重大新藥創(chuàng)制”科技重大專項(xiàng)、國家“863”項(xiàng)目、國家自然科學(xué)基金等國家級及省部級課題26項(xiàng)；帶領(lǐng)的科研團(tuán)隊(duì)獲得江蘇省“青藍(lán)工程”科技創(chuàng)新團(tuán)隊(duì)。近五年，獲授權(quán)發(fā)明專利10項(xiàng)，發(fā)表科研論文72篇，SCI論文37篇，出版著作5部。
榮獲國家級教學(xué)名師，入選教育部“新世紀(jì)優(yōu)秀人才支持計(jì)劃”，江蘇省“333高層次人才培養(yǎng)工程”第二層次培養(yǎng)對象，江蘇省“六大人才高峰”，獲全國高校優(yōu)秀青年教師獎（教育部霍英東教育基金會），江蘇省優(yōu)秀教育工作者等榮譽(yù)稱號。為國家優(yōu)秀教學(xué)團(tuán)隊(duì)帶頭人，國家精品課程《藥學(xué)生物化學(xué)基礎(chǔ)》課程負(fù)責(zé)人，獲國家級教學(xué)成果獎一等獎3項(xiàng)、國家級教學(xué)成果獎二等獎1項(xiàng)，獲江蘇省教學(xué)成果獎特等獎2項(xiàng)、江蘇省教學(xué)成果獎一等獎2項(xiàng)。獲江蘇省科技進(jìn)步三等獎2項(xiàng)。

研究生培養(yǎng)情況
已培養(yǎng)碩士研究生62名，博士研究生20名。

近期發(fā)表的代表性論文
1．Mingming Gao, Yue Tong, Hong Tian, Xiangdong Gao and Wenbing Yao. Recombinant production of mGLP-1 by coupling of refolding and intein-mediated self-cleavage (CRIS). Appl Microbiol Biotechnol. DOI 10.1007/s00253-012-4163-4
2．Mingming Gao, Yuhao Jin, Yue Tong, Hong Tian, Xiangdong Gao, Wenbing Yao. A site-specific PEGylated analog of exendin-4 with improved pharmacokinetics and pharmacodynamics in vivo. Journal of Pharmacy and Pharmacology. doi: 10.1111/j.2042-7158.2012.01545.x
3．Hong Tian, Yuan Guo, Xiangdong Gao,Wenbing Yao. PEGylation enhancement of pH stability of uricase via inhibitive tetramer dissociation. Journal of Pharmacy and Pharmacology. DOI: 10.1111/j.2042-7158.2012.01575.x
4．Wei Guo, Chen Luo, Chen Wang, Yue Zhu, Xin Wang, Xiangdong Gao, Wenbing Yao. Protection against Th17 Cells Differentiation by an Interleukin-23 Receptor Cytokine-Binding Homology Region. Plos One. 2012, 7(9): e45625
5．Mingming Gao , Yue Tong , Wen Li , Xiangdong Gao , Wenbing Yao. Improving the anti-diabetic activity of GLP-1 by fusion with globular adiponectin. Artificial Cells, Blood Substitutes, and Biotechnology. DOI: 10.3109/10731199.2012. 712042
6．Hai Chen, Yingfei Lu, Zhengzhi Fang, Jingxian Liu, Hong Tian, Xiangdong Gao and Wenbing Yao. High-level production of uricase containing keto functional groups for site-specific PEGylation. Biochemical Engineering Journal, 2011,58(59): 25-32
7．Zhengzhi Fang, Yaguang Liu, Jingxian Liu, Renhua Sun, Hai Chen, Xiangdong Gao, Wenbing Yao. Designing and engineering of a site-specific incorporation of a keto group in uricase. Chemical Biology & Drug Design, 2011, 78(3):353-360
8．Yuge Niu, Zhuohong Xie, JunJie Hao, WenBing Yao, Jin Yue, Liangli (Lucy) Yu. Preparation of succinylated derivatives of psyllium and their physicochemical and bile acid-binding properties. Food Chemistry, 2012,132: 1025–1032
9．Cao Jin, Meng Fang, Gao Xiangdong, Dong Hongxia, Yao Wenbing. Expression and Purification of a Natural N-Terminal Pre-ligand Assembly Domain of Tumor Necrosis Factor Receptor 1 (TNFR1 PLAD) and Preliminary Activity Determination. The Protein Journal, 2011, 30(4): 281-289
10．Yuge Niu, Hengyu Wang, Zhuohong Xie, Monica Whent, Xiangdong Gao, Xian Zhang, Shan Zou, Wenbing Yao, Liangli Yu. Structural Analysis and Bioactivity of a Polysaccharide from the Roots of Astragalus membranaceus (Fisch) Bge. var. mongolicus (Bge.) Hsiao. Food Chemistry, 2011, 128: 620–626
11．Jingjing Sun, Xiaoda Song, Hong Tian, Yuhao Jin, Xiangdong Gao, Wenbing Yao. Synthesis of a novel Histidine-Targeting poly(ethylene glycol) and modification of lysozyme. Journal of Applied Polymer Science, 2011, 119(4): 2183-2188
12．Ma Chen, Gao Mingming, Liu Wenchao, Zhu Jing, Tian Hong, Gao Xiangdong, Yao Wenbing. Intein-mediated Expression and Purification of an Analog of Glucagon-like Peptide-1 in Escherichia coli. Protein and Peptide Letters, 2010,17(10): 1245-1250
13．Mingming Gao, Chen Ma, Wenchao Liu, Jing Zhu, Hong Tian, Xiangdong Gao, Wenbing Yao. Production and purification of an analog of glucagon-like peptide-1 by auto-induction and on-column cleavage in Escherichia coli. World J Microbiol Biotechnol, 2010, 26(9): 1675–1682
14．Min Ren, Wei Yan, Wenbing Yao, Lei Jin, Xiangdong Gao. Enzymatic degradation products from a marine polysaccharide YCP with different immunological activity and binding affinity to macrophages, hydrolyzed by a-amylases from different origins. Biochimie, 2010,92:411-417
15．Wei Liu, Jing Xu, Pu Jing, Wenbing Yao, Xiangdong Gao, Liangli (Lucy) Yu. Preparation of a hydroxypropyl Ganoderma lucidum polysaccharide and its physicochemical properties. Food Chemistry, 2010, 122: 965–971
16．Wei Liu, Hengyu Wang, Wenbing Yao, Xiangdong Gao and Liangli (Lucy) Yu. Effects of Sulfation on the Physicochemical and Functional Properties of a Water-Insoluble Polysaccharide Preparation from Ganoderma lucidum. J. Agric. Food Chem., 2010, 58 (6): 3336–3341
17．Wei Liu, Zhuohong Xie, Boce Zhang, Qin Wang, Wenbing Yao, Xiangdong Gao and Liangli (Lucy) Yu. Effects of Hydroxypropylation on the Functional Properties of Psyllium.J. Agric. Food Chem., 2010, 58 (3): 1615–1621
18．Wei Liu, Boce Zhang, Qin Wang, Zhouhong Xie, Wenbing Yao, Xiangdong Gao and Liangli (Lucy) Yu. Effects of Sulfation on the Physicochemical and Functional Properties of Psyllium. J. Agric. Food Chem., 2010, 58 (1): 172–179
19．Wei Liu, Hengyu Wang, Xiubing Pang, Wenbing Yao, Xiangdong Gao. Characterization and antioxidant activity of two low-molecular-weight polysaccharides purified from the fruiting bodies of Ganoderma lucidum. International Journal of Biological Macromolecules,2010,46:451-457
20．Yue Tong, Kai Zhong, Hong Tian, Xiangdong Gao, Xiangyang Xu, Xiaojin Yin, Wenbing Yao. Characterization of a monoPEG20000-Endostar. International Journal of Biological Macromolecules,2010,46(3):331-336
21．Mingming Gao, Hong Tian, Chen Ma, Xiangdong Gao, Wei Guo and Wenbing Yao . Expression, Purification, and C-terminal Site-Specific PEGylation of Cysteine-Mutated Glucagon-Like Peptide-1. Applied Biochemistry and Biotechnology, 2010,162(1):155-165
22．Shan Zou, Xian Zhang, Wenbing Yao, Yuge Niu, Xiangdong Gao. Structure characterization and hypoglycemic activity of a polysaccharide isolated from the fruit of Lycium barbarum L. Carbohydrate Polymers, 2010,80:1161-1167
23．Renhua Sun, Heng Zheng, Zhengzhi Fang and Wenbing Yao. Rational design of aminoacyl-tRNA synthetase specific for p-acetyl-l-phenylalanine. Biochemical and Biophysical Research Communications, 2010, 391(1): 709-715
24．Jin Cao , Yu Du , Hong Tian , Xiangdong Gao , Wenbing Yao . Quantitative determination of pegylated consensus interferon in rhesus monkey serum using a competitive enzyme-linked immunosorbent assay. Immunopharmacol Immunotoxicol, 2009,31(4):543-549

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Email：wbyao@cpu.edu.cn

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