高向東 ，教授，博士生導(dǎo)師，生命科學(xué)與技術(shù)學(xué)院，院長(zhǎng)

主要經(jīng)歷
1963年7月生，畢業(yè)于中國(guó)藥科大學(xué)生物制藥專業(yè)和南京大學(xué)生命科學(xué)學(xué)院植物學(xué)專業(yè)，獲博士學(xué)位。1993年曾赴日本歧阜藥科大學(xué)分子生物實(shí)驗(yàn)室作訪問學(xué)者。
1983年留校任教以來(lái)，一直從事教學(xué)、科研和管理工作?，F(xiàn)任中國(guó)藥科大學(xué)微生物與生化藥學(xué)教授（博士生導(dǎo)師）、中國(guó)藥科大學(xué)生命科學(xué)與技術(shù)學(xué)院院長(zhǎng)。為國(guó)務(wù)院學(xué)位委員會(huì)第六屆學(xué)科評(píng)議組藥學(xué)組成員，國(guó)家食品藥品監(jiān)督管理局新藥、保健食品評(píng)審專家，中國(guó)藥學(xué)會(huì)生化與生物技術(shù)藥物專業(yè)委員會(huì)委員，中國(guó)生物化學(xué)與分子生物學(xué)會(huì)工業(yè)生物化學(xué)與分子生物學(xué)分會(huì)常務(wù)理事，中國(guó)微生物學(xué)會(huì)海洋藥物委員會(huì)理事，《中國(guó)藥科大學(xué)學(xué)報(bào)》、《藥物生物技術(shù)》、《藥學(xué)進(jìn)展》、《食品與藥品》等雜志編委。

主要科研工作簡(jiǎn)介：
主要從事的研究領(lǐng)域
生物新藥研制、生物大分子結(jié)構(gòu)與功能研究和衰老的分子生物學(xué)研究。

課題資助情況
在以上研究領(lǐng)域已主持完成了國(guó)家重大新藥創(chuàng)制項(xiàng)目、國(guó)家863項(xiàng)目、國(guó)家自然科學(xué)基金項(xiàng)目、教育部重點(diǎn)項(xiàng)目、江蘇省重點(diǎn)項(xiàng)目等國(guó)家及省部級(jí)課題24項(xiàng)。目前正主持“十二五” 國(guó)家重大新藥創(chuàng)制項(xiàng)目、海洋863項(xiàng)目、國(guó)家自然科學(xué)基金、博士點(diǎn)基金等項(xiàng)目6項(xiàng)。

完成的主要科研工作及獲獎(jiǎng)情況
長(zhǎng)期從事生物新藥的研制、生物大分子結(jié)構(gòu)與功能研究及衰老的分子生物學(xué)研究，在以上研究領(lǐng)域已主持完成了國(guó)家重大新藥創(chuàng)制項(xiàng)目、國(guó)家863項(xiàng)目、國(guó)家自然科學(xué)基金項(xiàng)目、博士點(diǎn)基金等國(guó)家及省部級(jí)課題24項(xiàng)，主持研發(fā)的“卡介菌多糖膠囊”、“蘄蛇酶注射液”已獲國(guó)家新藥證書；獲授權(quán)發(fā)明專利10項(xiàng)；近五年，發(fā)表科研論文83篇，其中SCI論文42篇，出版著作6部。
榮獲第四屆教育部“高校青年教師獎(jiǎng)”，享受政府特殊津貼，江蘇省教學(xué)名師，江蘇省“三八”紅旗手，“江蘇省優(yōu)秀教育工作者”，江蘇省高?！凹t杉樹”園丁獎(jiǎng)，江蘇省“333高層次人才培養(yǎng)工程”中青年科學(xué)技術(shù)帶頭人，江蘇省“六大人才高峰”優(yōu)秀人才。 國(guó)家級(jí)教學(xué)團(tuán)隊(duì)“生物制藥工藝學(xué)課程教學(xué)團(tuán)隊(duì)”帶頭人，國(guó)家精品課程《生物制藥工藝學(xué)》課程負(fù)責(zé)人，獲江蘇省教學(xué)成果一等獎(jiǎng)、二等獎(jiǎng)各一項(xiàng)。

研究生培養(yǎng)情況
已培養(yǎng)碩士研究生92名，博士研究生30名。

近期發(fā)表的代表性論文
[1] Guo W, Luo C, Wang C, Zhu Y, Wang X, Gao XD. Protection against Th17 Cells Differentiation by an Interleukin-23 Receptor Cytokine-Binding Homology Region. 2012, 7(9): e45625
[2] Chen S, Liu AR, An FM, Yao WB, Gao XD. Amelioration of neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer’s disease by exendin-4. AGE. 2012, 34(5):1211-1224
[3] Jin L, Guan X, Liu W, Zhang X, Yan W, Yao WB, Gao XD. Characterization and antioxidant activity of a polysaccharide extracted from Sarcandra Glabra. Carbohydr Polym. 2011, 90(1): 524-532
[4] Niu YG, Wang HY, Xie ZH, Whent M, Gao XD, Zhang X, Zou S, Yao WB, Yu LL. Structural Analysis and Bioactivity of a Polysaccharide from the Roots of Astragalus membranaceus (Fisch) Bge. var. mongolicus (Bge.) Hsiao. Food Chem. 2011, 128(3): 620–626
[5] Wang JJ, Zhao H, Zheng Y, Liu W, Zhou H, Han ARN, Gao XD. Monoclonal Antibodies to Sea Cucumber Polysaccharide and Their Use in a Sandwich ELISA Assay. Hybridoma. 2011, 30(4): 381-385
[6] Sun JJ, Song XD, Tian H, Jin YH, Gao XD, Yao WB. Synthesis of a novel Histidine-Targeting poly (ethylene glycol) and modification of lysozyme. Journal of Applied Polymer Science. 2011, 119(4): 2183-2188
[7] Ren M, Yan W, Yao WB, Jin L, Gao XD. Enzymatic degradation products from a marine polysaccharide YCP with different immunological activity and binding affinity to macrophages, hydrolyzed by α-amylases from different origins. Biochimie. 2010, 92(4): 411-417
[8] Liu W, Wang HY, Yao WB, Gao XD, Yu LL. Effects of Sulfation on the Physicochemical and Functional Properties of a Water-Insoluble Polysaccharide Preparation from Ganoderma lucidum. J Agr Food Chem. 2010, 58(6): 3336–3341 (IF2.469)
[9] Liu W, Xie ZH, Zhang BC, Wang Q, Yao WB, Gao XD and Yu LL. Effects of Hydroxypropylation on the Functional Properties of Psyllium. J Agr Food Chem. 2010, 58(3): 1615–1621
[10] Liu W, Zhang BC, Wang Q, Xie ZH, Yao WB, Gao XD and Yu LL. Effects of Sulfation on the Physicochemical and Functional Properties of Psyllium. J Agr Food Chem. 2010, 58(1): 172–179
[11] Liu W, Wang HY, Pang XB, Yao WB, Gao XD. Characterization and antioxidant activity of two low-molecular-weight polysaccharides purified from the fruiting bodies of Ganoderma lucidum. Int J Biol Macromol. 2010, 46(4): 451-457
[12] Tong Y, Zhong K, Tian H, Gao XD, Xu XY, Yin XJ, Yao WB. Characterization of a mono PEG20000-Endostar. Int J Biol Macromol. 2010, 46(3): 331-336
[13] Ma C, Gao MM, Liu WC, Zhu J, Tian H, Gao XD, Yao WB. Intein-mediated Expression and Purification of an Analog of Glucagon-like Peptide-1 in Escherichia coli. Protein Pept Lett. 2010, 17(10): 1245-1250
[14] Gao MM, Ma C, Liu WC, Zhu J, Tian H, Gao XD, Yao WB. Production and purification of an analog of glucagon-like peptide-1 by auto-induction and on-column cleavage in Escherichia coli. World J Microbiol Biotechnol. 2010, 26(9): 1675–1682
[15] Gao MM, Tian H, Ma C, Gao XD, Guo W, Yao WB. Expression, Purification, and C-terminal Site-Specific PEGylation of Cysteine-Mutated Glucagon-Like Peptide-1. Appl Biochem Biotechnol. 2010, 162(1): 155-165
[16] Liu W, Xu J, Jing P, Yao WB, Gao XD, Yu LL. Preparation of a hydroxypropyl Ganoderma lucidum polysaccharide and its physicochemical properties. Food Chem. 2010, 122(4): 965–971
[17] Zou S, Zhang X, Yao WB, Niu YG, Gao XD. Structure characterization and hypoglycemic activity of a polysaccharide isolated from the fruit of Lycium barbarum L. Carbohydr Polym. 2010, 80(4): 1161-1167
[18] Song XD, Sun JJ, Tian H, Gao XD. Gold nanoparticles combined with highly expressed amber suppressor tRNA: a future antibacterial agent. Irn J Med Hypotheses Ideas. 2010, 4: 6
[19] Xu J, Liu W, Yao WB, Pang XB, Yin DK, Gao XD. Carboxymethylation of a polysaccharide extracted from Ganoderma lucidumen hances its antioxidant activities in vitro. Carbohydr Polym. 2009, 78(2): 227–234
[20] Chen S, Yin DK, Yao WB, Wang YD, Zhang YR, Gao XD. Macrophage receptors of polysaccharide isolated from a marine filamentous fungus Phoma herbarum YS4108. Acta Pharmacologica Sinica. 2009, 30(7): 1008-1014
[21] Yin DK, Yao WB, Chen S, Hu RF, Gao XD. Salidroside, the Main Active Compound of Rhodiola Plants, Inhibits High Glucose-Induced Mesangial Cell Proliferation. Planta Med. 2009, 75(11): 1191-1195

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